PL
Po 90-dniowym narażeniu szczurów, w odstępach dobowych, na pojedyncze i łączne działanie Pb(CH3COO)2 i NaNO2 oznaczono aktywność peroksydazy glutationowej (GSH-Px; E.C.1.11.1.9.), dehydrogenazy mleczanowej (LDH; E.C.1. 1.1.27.) oraz dysmutazy ponadtlenkowej (SOD; E.C.1.15.1.1.). Stwierdzono istotne zmiany aktywności GSH-Px we wszystkich badanych grupach. Wzrost aktywności LDH zaobserwowano jedynie w grupie otrzymującej azotyn sodu.
EN
Mille Wistar rats for 3 months received per os: 1) distilled water (control); 2) 30 mg/kg b.w. per diem sodium nitrite (20% LD50); 3) 10 mg/kg b.w. per diem lead (II) acetate (6,7% LD50); 4) lead (II) acetate and sodium nitrite in amounts per diem as above. Activities of glutathione peroxidase (E.C. 1.11.1.9), lactate dehydrogenase (E.C.1. 1.1.27) and superoxide dismutase (E.C. 1.15.1.1.) in erythrocytes of all test animals were determined. Significant changes of glutathione peroxidase activity were shown to occur in all treated groups. Increased lactate dehydrogenase activity was observed only in the group receiving sodium nitrite. Changes in the activity of superoxide dismutase were not significant in any of the examined groups. It is quite likely that, at low methaemoglobin concentrations (in lead-poisoned rats), the main mechanism of methaemoglobin reduction is associated with glutathione peroxidase activation, while at higher methaemoglobin concentrations (in sodium nitrite poisoning), enzyme systems using reduced adenine dinucleotides are essential for methaemoglobin reduction.