Central histamine-induced reversal of critical haemorrhagic hypotension in rats - haemodynamic studies

• Autorzy: Jochem J.
• Języki publikacji: EN

Abstrakty

EN

Volume-controlled irreversible haemorrhagic shock in rats produced by blood withdrawal until stabilisation of critical mean arterial pressure (MAP)20-25 mmHg is associated with an extreme decrease in cardiac index (CI)and an increase in total peripheral resistance index (TPRI),with reductions in renal (RBF),hindquarters (HBF)and mesenteric blood flow (MBF),and leads to the death of all control animals within 30 min.Histamine (100 nmol)injected intracerebroventricularly (i.c.v.)in the early phase of critical hypotension produces a prompt and long-lasting increase in MAP and heart rate,with a 100%survival for 2 h after treatment.The effects are associated with the rise in the circulating blood volume and CI,and the decrease in TPRI,with the increase in RBF and HBF,and persistently lowered MBF.Both splenectomy and ligation of the suprahepatic veins inhibit histamine-induced increase in circulating blood volume as well as cardiac and regional haemodynamic effects.It can be concluded that histamine administered icv activates central endogenous compensatory mechanisms,which leads to the reversal of haemorrhagic shock conditions due to the mobilisation of blood from venous reservoirs,the increase in circulating blood volume and its redistribution.Moreover,histamine evokes the rises in CI and perfusion of the renal and skeletal muscle vascular regions.

Słowa kluczowe

EN

histamine; histaminergic system; hemorrhagic shock; cardiovascular regulation; hemorrhagic hypotension; rat

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2002
• Tom: 53
• Numer: 1
• Opis fizyczny: p.75-84,fig.

Twórcy

autor

Jochem J.

• Silesian Medical University, H.Jordana 19, 41-808 Zabrze, Poland