Fibronectin fragments in human seminal plasma

• Autorzy: Katnik-Prastowska I. , Przybysz M. , Chelmonska-Soyta A.
• Języki publikacji: EN

Abstrakty

EN

The study has revealed the presence of fibronectin (FN) fragments and a lack of intact FN in 72 seminal plasma samples. The FN fragmentation was examined by immunoblotting with a monoclonal antibody specific to the central cellular FN domain and was confirmed with a monoclonal antibody directed to the C-terminal domain of FN. Nine FN fragments between 60 and 200 kDa and five fragments of 60–150 kDa were identified in seminal plasma samples of normozoospermic and of terato-, oligoterato-, and oligoasthenoterato-spermic groups, respectively. The relative amounts of the 60, 90 and 100 kDa FN fragments were 2–3 times higher in seminal plasmas with abnormal semen characteristics than in the normozoospermic group. The results suggest that seminal plasma FN fragments may contribute to fertilization and the analysis of FN fragmentation may have a diagnostic value in andrological investigations.

Słowa kluczowe

EN

man; cellular domain; adhesive glycoprotein; fibronectin; seminal plasma; cellular regulation process

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2005
• Tom: 52
• Numer: 2
• Opis fizyczny: p.557-560,fig.,ref.

Twórcy

autor

Katnik-Prastowska I.

• Medical University, Wroclaw, Poland

autor

Przybysz M.

autor

Chelmonska-Soyta A.

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