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2010 | 59 | 1 |

Tytuł artykułu

Antimicrobial susceptibility of metallo-beta-lactamase positive and negative Klebsiella pneumoniae strains isolated from intensive care unit patients

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Carbapenem resistance in Gram-negative bacteria is a worldwide increasing and one of the most disturbing problems, given these antibiotics are drugs of choice in the treatment of infections caused by extended-spectrum-beta-lactamase producing strains. In this study the antibiotic susceptibility of metallo-beta-lactamase-positive and negative Klebsiella pneumoniae strains isolated from intensive care unit (ICU) patients was evaluated. The presence of genes encoding MBLs was determined with a commercial kit hyplex® MBL ID (BAG HEALTH CARE). The MBL-producing isolates were the first K.pneumoniae isolates of this kind identified in Poland. It seems that methods for detecting MBLs in Enterobacteriaceae should be included in contemporary standards of microbiological diagnostics in the country.

Wydawca

-

Rocznik

Tom

59

Numer

1

Opis fizyczny

p.67-69,fig.,ref.

Twórcy

autor
  • Nicolas Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland
autor
autor

Bibliografia

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  • Cornaglia G., A. Mazzariol, L. Lauretti, G.M. Rossolini and R. Fontana. 2000. Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-ä-lactamase. Clin. Infect. Dis. 31: 1119-1125.
  • Empel J., A. Baraniak, E. Literacka, A. Mrówka, J. Fiett, E. Sadowy, W. Hryniewicz, M. Gniadkowski and the Beta-PL Study Group. 2008. Molecular survey of ß-lactamases conferring resistance to newer ß-lactams in Enterobacteriaceae isolates from Polish hospitals. Antimicrob. Agents Chemother. 52: 2449-2454.
  • Giakkoupi P., A. Xanthaki, M. Kanelopoulou, A. Vlahaki, V. Miriagou, S. Kontou, E. Papafraggas, H. Malamou-Lada, L.S. Tzouvelekis, N. J. Legakis and others. 2003. VIM-1 metallo-ß-lactamase-producing Klebsiella pneumoniae strains in Greek hospitals. J. Clin. Microbiol. 41: 3893-3896.
  • Hryniewicz W., A. Sulikowska, K. Szczypa, A. Skoczyńska, A. Łuczak-Kadłubowska and M. Gniadkowski. 2006. Recommendations on antimicrobial susceptibility testing (in Polish). Narodowy Instytut Zdrowia Publicznego. Warsaw. Poland
  • Jarlier V., M. Nicolas, G. Fournier and A. Philippon. 1988. Extended broad-spectrum ß-lactamases conffering transferable resistance to newer ß-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Rev. Infect. Dis. 10: 867-878.
  • Kassis-Chikhani N., D. Decré, V. Gautier, B. Burghoffer, F. Saliba, D. Mathieu, D. Samuel, D. Casting, J.C. Petit, E. Dussaix and others. 2006. First outbreak of multidug-resistant Klebsiella pneumoniae carrying blaVIM-1 and blaSHV-5 in a French university hospital. J. Antimicrob. Chemother. 57: 142-145.
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  • Luzzaro F., J.D. Docquier, C. Colinon, A. Endimiani, G. Lombardi, G. Amicosante, G.M. Rossolini and A. Toniolo. 2004. Emergence in Klebsiella pneumoniae and Enterobacter cloacae clinical isolates of the VIM-4 metallo-ß-lactamase encoded by a conjugative plasmid. Antimicrob. Agents Chemother. 48: 648-650.
  • Pournaras S., A. Ikonomidis, L.S. Tzouvelekis, D. Tokatlidou, N. Spanakis, A. N. Maniatis, N. J. Legakis and A. Tsakris. 2005. VIM-12 a novel plasmid mediated metallo-ß-lactamase from Klebsiella pneumoniae that resembles a VIM-l/VIM-2 hybrid. Antimicrob. Agents Chemother. 49: 5153-5156.
  • Queenan A.M. and K. Bush. 2007. Carbapenemases: the versatile ß-lactamases. Clin. Microb. Rev 20: 440-458.
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  • Toraman Z.A., Y. Yakupogullari and A. Kizirgil. 2004. Detection of metallo ß-lactamase production and antibiotic resistance with E-test method in pseudomonas, acinetobacter and klebsiella strains, in Turkey. J. Infect. Chemother. 10: 257-261.
  • Türtola M.T., S. Lavilla, E. Mirü, J.J. González, N. Larrosa, M. Sabaté M, F. Navarro and G. Prats. 2005. First detection of a carbapenem-hydrolysing metalloenzyme in two Enterobacteriaceae isolates in Spain. Antimicrob. Agents Chemother. 49: 3492-3494.
  • Watanabe M., S. Iyobe and M. Inouc. 1991. Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrob, Agents Chemother. 35: 147-151.
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Typ dokumentu

Bibliografia

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