Zmiany w watrobie szczura w poznym okresie zatrucia chlorfenwinfosem w dawce jednorazowej

• Autorzy: Lukaszewicz-Hussain A. , Moniuszko-Jakoniuk J.
• Języki publikacji: PL

Abstrakty

PL

Zbadano wpływ podania chlorfenwinfosu na aktywność enzymów wątrobowych w surowicy krwi i homogenacie wątroby szczura, 48 h po podaniu tego związku w dawce jednorazowej.

EN

The present investigation was undertaken to study the effect of chlorphenvinphos on the activity of liver enzymes in acute poisoning with this compound. The investigation was caried out on male Wistar rats. The animals received oil - control group and oil solution of chlorphenvinphos in dose 0,5 or 0,1 LD50 - the examined group intragastrically. Material for examination was collected in the 48 h after intoxication. Activity of GOT and GPT in a serum, cytosolic and mitochondrial fractions of liver; BGR and AcP in a serum and lysosomal fraction of liver, ChE in a serum and concentration of lactate in the cytosolic fraction of liver were assayed. It can be concluded that in the 48 h after intoxication with chlorphenvinphos, activity of ChE was normalized in the case of lower dose and has such tendency in the case of higher dose. The changes of other assayed parameters in the serum and liver homogenate indicates that in this period of study, the liver is in point of no return.

Słowa kluczowe

PL

surowica krwi; szczury; enzymy watrobowe; zwierzeta laboratoryjne; chlorfenwinfos; aktywnosc enzymatyczna; toksykologia; insektycydy; watroba

EN

blood serum; rat; liver enzyme; laboratory animal; chlorfenvinphos; enzyme activity; toxicology; insecticide; liver

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 1998
• Tom: 49
• Numer: 3
• Opis fizyczny: s.313-319,tab.,bibliogr.

Twórcy

autor

Lukaszewicz-Hussain A.

• Akademia Medyczna, 15-222 Bialystok, ul.Mickiewicza 2

autor

Moniuszko-Jakoniuk J.