A new look at adaptive mutations in bacteria

• Autorzy: Janion C.
• Języki publikacji: EN

Abstrakty

EN

This is a short survey of the adaptive mutation processes that arise in non- or slowly- dividing bacterial cells and includes: (i) bacterial models in which adaptive mutations are studied; (ii) the mutagenic lesions from which these mutations derive; (iii) the influence of DNA repair processes on the spectrum of adaptive mutations. It is proposed that in starved cells, likely as during the MFD phenomenon, lesions in tRNA suppressor genes are preferentially repaired and no suppressor tRNAs are formed as a result of adaptive mutations. Perhaps the most provocative proposal is (iv) a hypothesis that the majority of adaptive mutations are selected in a pre-apoptotic state where the cells are either mutated, selected, and survive, or they die.

Słowa kluczowe

EN

DNA repair; DNA damage; adaptive mutation; bacterial cell; bacteria; mutation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 2
• Opis fizyczny: p.451-457

Twórcy

autor

Janion C.

• Polish Academy of Sciences, A.Pawinskiego 5a, 02-106 Warsaw, Poland

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