PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2004 | 55 | 3 |

Tytuł artykułu

Human cytomegalovirus DNA level in patients with idiopathic pulmonary fibrosis

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The objectives of the study were to estimate human cytomegalovirus (HCMV) DNA copy number in broncho-alveolar lavage cells, blood leukocytes, and serum of patients with idiopathic pulmonary fibrosis (IPF). The study groups consisted of 16 patients, newly diagnosed with IPF and never treated, (mean age 40.9 ±11.0 yr; F/M-7/9) and in 16 adult healthy volunteers (mean age 36.8 ±6.4 yr; F/M-4/12) used as controls. The HCMV DNA copy number was calculated by a Q-PCR method using TaqMan ABI PRISMTM7700. We found that the prevalence of the HCMV DNA positive subjects in the patient group (75%) did not differ significantly from that in the control group (69%). We also found that in both patient and control groups the mean HCMV DNA copy number in BAL cells was significantly higher than that in blood leukocytes (log10=2.7 vs. 1.2 for patients and 2.8 vs. 0.9 for controls, respectively). However, a higher HCMV DNA copy number in blood serum was observed in IPF patients than in controls (log10=3.2 vs. 2.0, respectively). We conclude that the lungs play an important role in the human pathobiology of cytomegalovirus sustenance.

Wydawca

-

Rocznik

Tom

55

Numer

3

Opis fizyczny

p.67-75,fig.,ref.

Twórcy

  • Medical University of Silesia, 1 Koziolka ST., 41-803 Zabrze, Poland
autor
autor
autor
autor
autor
autor
autor

Bibliografia

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-a3c55f35-1fd8-4019-97e2-3c7c043eed48
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.