Motifs with potential physiological activity in food proteins - BIOPEP database

• Autorzy: Iwaniak A. , Dziuba B.

Warianty tytułu

PL

Motywy o potencjalnej fizjologicznej aktywnosci w bialkach zywnosci - baza danych BIOPEP

• Języki publikacji: EN

Abstrakty

EN

Proteins are the multifunctional food components affecting the living organ-isms. One of the proteins function is the impact on the body due to the presence of motifs that show specific physiological and biological activities. Due to the worldwide growth of demand for the food containing bioactive components, increasing attention has been paid recently to the use of bioactive peptides as physiologically active food ingredients. They are important elements of the prevention and treatment of various lifestyle diseases. In addition to its primary function and according to current knowledge, each protein may be a reserve source of peptides controlling the life processes of organisms. For this reason, in this work, application of a new, additional criterion for evaluating proteins as a potential source of biologically active peptides, contributes to a more comprehensive and objective definition of their biological value. A complementary part of such research is the strategy for evaluation of the food proteins as precursors of biologically active peptides which involves the database of proteins and bioactive peptides - BIOPEP (available on-line at: http://www.uwm.edu.pl/biochemia). The database contains information on 2123 peptides representing 48 types of bioactivities, their EC50 values and source of origin. Proteins (706 sequences) are considered as bioactive peptide precursors based on newly introduced criteria: the profile of potential biological activity, the frequency of bioactive fragments occurrence and potential biological protein activity. This original and unprecedented so far approach, started to be successfully and more widely applied by other authors. BIOPEP can be interfaced with global databases such as e.g. TrEMBL, SWISS-PROT, EROP and PepBank. Recently the BIOPEP database was enlarged with the data about allergenic proteins, including information about structure of their epitopes and molecular markers

PL

Białka to wielofunkcyjne składniki żywności, które oddziałują na żywe organizmy. Jedną z funkcji białek jest ich wpływ na organizm wynikający z obecności mo-tywów, które wykazują specyficzne funkcje fizjologiczne i biologiczne. Ze względu na rosnące zapotrzebowanie na produkty żywnościowe zawierające składniki bioaktywne, dużą uwagę zwraca się na zastosowanie bioaktywnych peptydów jako fizjologicznie aktywnych składników żywności, odgrywających ważną rolę w zapobieganiu i leczeniu różnych chorób wynikających ze stylu życia. Według aktualnego stanu wiedzy, poza swą podstawową funkcją, białka mogą być rezerwą peptydów kontrolujących procesy zachodzące w organizmach żywych. Dlatego zastosowanie nowego, dodatkowego kryterium oceny białek jako prekursorów bioaktywnych peptydów przyczynia się do kompleksowego oraz obiektywnego definiowania wartości biologicznej białka. Komplementarną częścią takich badań jest strategia oceny białek - prekursorów bioaktywnych peptydów opar-ta na wykorzystaniu bazy danych sekwencji białek i bioaktywnych peptydów BIOPEP (dostępnej pod adresem: http://www.uwm.edu.pl/biochemia). Baza zawiera informacje na temat 2123 peptydów reprezentujących 48 rodzajów aktywności biologicznych, wartości EC50 oraz źródła pochodzenia. Białka (706 sekwencji) są rozpatrywane jako prekursory bioaktywnych peptydów z wykorzystaniem nowo wprowadzonych kryteriów, tj.: profilu potencjalnej aktywności biologicznej, częstości występowania bioaktywnych fragmentów i potencjalnej aktywności biologicznej białka. To oryginalne i niespotykane dotychczas podejście, zaczyna być coraz częściej z powodzeniem stosowane przez innych autorów. BIOPEP może współdziałać z innymi światowymi bazami danych, np.: TrEMBL, SWISS-PROT, EROP i PepBank. Ponadto baza danych BIOPEP została powiększona o dane dotyczące białek alergennych wraz z informacjami na temat struktury ich epitopów oraz markerów molekularnych.

Słowa kluczowe

EN

bioactive peptide; peptide; physiological activity; food protein; protein; BIOPEP database

• Wydawca: -
• Czasopismo: Acta Scientiarum Polonorum. Technologia Alimentaria
• Rocznik: 2009
• Tom: 08
• Numer: 3
• Opis fizyczny: p.59-85,fig.,ref.

Twórcy

autor

Iwaniak A.

• University of Warmia and Mazury in Olsztyn, Cieszynski Square 1, 10-957 Olsztyn, Poland

autor

Dziuba B.

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