Peroxidation-antioxidation imbalance after severe burn injury

• Autorzy: Szpringer E. , Marciniak A. , Gorny D. , Beltowski J. , Lutnicki K. , Czerny K.
• Języki publikacji: EN

Abstrakty

EN

Severe burn injury is associated with damage of tissues and organs distant to the area of injury. Although different agents are suggested to play an important role in pathogenesis of the burn disease, disturbed balance between the development of reactive oxygen forms and activity of antioxidants can play a pivotal role. Therefore, the aim of our study was to examine the intensity of lipid peroxidation process in plasma and lung tissues as well as the antioxidant ability of rats subjected to severe burn injury during 48 hrs after the injury. Our results show that severe burn injury causes a significant increase in the level of lipid peroxides in plasma and lung tissues, with a concomitant increase in superoxide dismutase (Cu-Zn SOD) activity in erythrocytes during 48 hrs of the postburn period. Glutathione peroxidase (Se-GPx) activity in whole blood was significantly higher during the first postburn day and then decreased becoming lower than that found in the healthy subjects. Total Antioxidant Status (TAS) and the level of uric acid in plasma also increased. Thus, we conclude that severe burn injury causes the imbalance between the intensity of the lipid peroxidation process and the antioxidant ability of the organism and this can play an important role in the pathophysiology of the burn disease.

Słowa kluczowe

EN

superoxide dismutase; total antioxidant status; pathogenesis; reactive oxygen form; organ; antioxidation; burn disease; glutathione peroxidase; lipid hydroperoxide; burn injury; malonyldialdehyde; free radical; antioxidant; peroxidation; tissue

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2000
• Tom: 03
• Numer: 1
• Opis fizyczny: p.39-45,fig.

Twórcy

autor

Szpringer E.

• Medical Academy in Lublin, Jaczewskiego 8, 20-090 Lublin 1, Poland

autor

Marciniak A.

autor

Gorny D.

autor

Beltowski J.

autor

Lutnicki K.

autor

Czerny K.