Protein kinase signalling cascade during nitric oxide-induced apoptosis, dedifferentiation and inflammatory responses of articular chondrocytes

• Autorzy: Chun J S
• Języki publikacji: EN

Słowa kluczowe

EN

dedifferentiation; inflammatory response; cascade; chondrocyte; signalling; apoptosis; protein kinase

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 2A
• Opis fizyczny: p.512-513

Twórcy

autor

Chun J S

• Kwangju Institute of Science and Technology, Gwangju 500-712, Korea

Bibliografia

• 1. Kim, S.J., Ju, J.W., Oh, C.D., Yoon, Y.M., Song, W.K., Kim, J.H, Yoo, Y.J., Bang, O.S., Kang, S.S. and Chun, J.S. ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3 and differentiation status. J. Biol. Chem. 277 (2002) 1332-1339.
• 2. Yoon, Y.M., Kim, S.J., Oh, C.D., Ju, J.W., Song, W.K., Yoo, Y.J., Huh, T.L. and Chun, J.S. Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinase. J. Biol. Chem. 277 (2002) 8412-8420.
• 3. Kim, S.J., Kim, H.G., Oh, C.D., Hwang, S.G., Song, W.K., Yoo, Y.J., Kang, S.S. and Chun, J.S. p38 kinase-dependent and -independent Inhibition of protein kinase C zeta and -alpha regulates nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes. J. Biol. Chem. 277 (2002) 30375-30381.
• 4. Kim, S.J., Hwang, S.G., Shin, D.Y., Kang, S.S. and Chun, J.S. p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J. Biol. Chem. 277 (2002) 33501-33508.
• 5. Kim, S.J. and Chun, J.S. Protein kinase Cα and ζ regulate nitric oxide-induced NFkB activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochem. Biophys. Res. Commun. 303 (2003) 206-211.
• 6. Yoon, J.B., Kim, S.J., Hwang, S.G., Chang, S., Kang, S.S. and Chun, J.S. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of the regulation of cyclooxygenase activity. J. Biol. Chem. 278 (2003) 15319-15325.