Function of heart muscle in people chronically exposed to lead

• Autorzy: Kasperczyk S. , Przywara-Chowaniec B. , Kasperczyk A. , Rykaczewska-Czerwinska M. , Wodniecki J. , Birkner E. , Dziwisz M. , Krauze-Wielicka M.
• Języki publikacji: EN

Abstrakty

EN

Rhythm and conductivity disturbances in heart muscle, change in autonomic system function and raised arterial blood pressure have been described in workers exposed to lead. They may be accompanied by changes in echocardiography test and accordingly we undertook this investigation. The study population included employees of zinc and lead steelworks in the south of Poland that were divided into 2 groups: exposed to lead compounds (n=88) and the reference group - administration workers (n=55) with normal levels of lead concentration in blood (PbB) and zinc protoporphyrin in blood. Left ventricular enddiastolic dimension (LVDd), interventricular septal and posterior wall thickness, right ventricular diastolic, left atrium diameter, aortic diameter and left ventricular ejection fraction (EF) in echocardiograms were performed. Left ventricular mass LVM (g) and left ventricular mass index LVMI (g/m2) was calculated. In the group exposed to lead, EF decreased by 3%, increased LVDd by 6%, and raised LVM by 11% and LVMI by 10%. There was a positive relation between PbB and LVDd (R=0.18) and between PbB and LVM (R=0.14). Decreased EF, enlargement of the left ventricle and raised left ventricle mass in research undertaken, may be a result of raised arterial blood tension.

Słowa kluczowe

EN

people; heart muscle; muscle function; lead exposure; arterial blood pressure; worker; lead; echocardiography; zinc; disturbance

• Wydawca: -
• Czasopismo: Annals of Agricultural and Environmental Medicine
• Rocznik: 2005
• Tom: 12
• Numer: 2
• Opis fizyczny: p.207-210,ref.

Twórcy

autor

Kasperczyk S.

• Silesian Medical University in Katowice, Jordana 19, 41-808 Zabrze, Poland

autor

Przywara-Chowaniec B.

autor

Kasperczyk A.

autor

Rykaczewska-Czerwinska M.

autor

Wodniecki J.

autor

Birkner E.

autor

Dziwisz M.

autor

Krauze-Wielicka M.

Bibliografia

• 1. Carmignani M, Volpe AR, Boscolo P, Qiao N, Di-Gioacchino M, Grilli A, Felaco M: Catcholamine and nitric oxide systems as targets of chronic lead exposure in inducing selective functional impairment. Life Sci 2000, 68, 401-415.
• 2. Carsia RV, Forman D, Hock CE, Nagele RG, Mcllroy PJ: Lead alters growth and reduces angiotensin II receptor density of rat aortic smooth muscle cells. Proc Soc Exp Biol Med 1995, 210, 180-190.
• 3. Chang HR, Chen SS, Tsao DA, Cheng JT, Ho CK, Yu HS: Change of cardiac beta-adrenoceptors in lead-exposed rats. Toxicology 1997,123, 27-32.
• 4. Chang HR, Chen SS, Tsao DA, Cheng JT, Ho CK, Yu HS: Reduced vascular beta-adrenergic receptors and catecholamine response in rats with lead induced hypertension. Arch Toxicol 1997, 71, 778-781.
• 5. Chang HR, Tsao DA, Yu HS, Ho CK: The change of beta- adrenergic system after cessation of lead exposure. Toxicology 2005, 207,73-80.
• 6. Cheng Y, Schwartz J, Vokonas PS, Weiss ST, Aro A, Hu H: Electrocardiographic conduction disturbances in association with low- level lead exposure (the Normative Aging Study). Am J Cardiol 1998, 82, 594-599.
• 7. Dalloz F, Maupoil V, Lecour S, Briot F, Rochette L: In vitro studies of interactions of NO. donor drugs with superoxide and hydroxyl radicals. Mol Cell Biochem 1997, 177, 193-200.
• 8. Ding Y, Gonick HC, Vaziri ND: Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells. Am J Hypertens 2000,13, 552-555.
• 9. Dreher D, Junod AF: Differential effects of superoxide, hydrogen peroxide, and hydroxyl radical on intracellular calcium in human endothelial cells. J Cell Physiol 1995, 162, 147-153.
• 10. Gajek J, Zysko D, Chlebda E: Heart rate variability in workers chronically exposed to lead. Kardiol Pol 2004, 61, 21-30.
• 11. Gonick HC, Ding Y, Bondy SC, Ni Z, Vaziri ND: Lead-induced hypertension: interplay of nitric oxide and reactive oxygen species. Hypertension 1997, 30, 1487-1492.
• 12. Grabecki J, Haduch T, Urbanowicz H: Die einfachen Bestimmungsmethoden der delta-Aminolavulinsaure im Harn. [Simple determination methods of delta-aminolevulinic acid in urine]. Int Arch Arbeitsmed 1967, 23, 226-240.
• 13. Gurer H, Ercal N: Can antioxidants be beneficial in the treatment of lead poisoning? Free Radie Biol Med 2000, 29, 927-945.
• 14. Hejtmancik M, Williams BJ: Time and level of perinatal lead exposure for development of norepinephrine cardiotoxicity. Res Commun Chem Pathol Pharmacol 1979, 24, 367-376.
• 15. Kasperczyk S, Birkner E, Kasperczyk A, Kasperczyk J: Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead. Hum Exp Toxicol 2005, 24(6), 287-295.
• 16. Kasperczyk S, Birkner E, Kasperczyk A, Zalejska-Fiolka J: The activity of superoxide dismutase and catalase in people protractedly exposed to lead compounds. Ann Agric Environ Med 2004,11, 291-296.
• 17. Kasperczyk S, Dziwisz M, Kasperczyk A, Birkner E: Wpływ ołowiu na występowanie nadciśnienia tętniczego. [Influence of lead exposure on arterial hypertension]. Wiad Lek 2002, 55, 230-234.
• 18. Kasperczyk S, Kasperczyk A, Ostałowska A, Dziwisz M, Birkner E: Activity of glutathione peroxidase, glutathione reductase and lipid peroxidation in erythrocytes in workers exposed to lead. Biol Trace Elem Res 2004,102, 61-72.
• 19. Konstantinova M: Ballistocardiographic and electrocardiographic changes in men working with lead. Bibl Cardiol 1975, (33), 101-104.
• 20. Korrick SA, Hunter DJ, Rotnitzky A, Hu H, Speizer FE: Lead and hypertension in a sample of middle-aged women. Am J Public Health 1999, 89,330-335.
• 21. Levy D, Savage DD, Garrison RJ, Anderson KM, Kannel WB, Castelli WP: Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study. Am J Cardiol 1987, 59, 956-960.
• 22. Ni Z, Hou S, Barton CH, Vaziri ND: Lead exposure raises superoxide and hydrogen peroxide in human endothelial and vascular smooth muscle cells. Kidney Int 2004, 66, 2329-2336.
• 23. Pfister E, Bockelmann I, Ferl T: Vegetative function diagnosis for early detection of lead intoxication. Int Arch Occup Environ Health 1996, 69, 14-20.
• 24. Skoczyńska A, Stojek E, Górecka H, Wojakowska A: Serum vasoactive agents in lead-treated rats. Int J Occup Med Environ Health 2003,16, 169-177.
• 25. Sroczyński J, Biskupek K, Piotrowski J, Rudzki H: Wpływ ołowiu występującego na stanowisku pracy wspólnie z cynkiem i kadmem na niektóre wskaźniki układu krążenia u pracowników przemysłu metalurgicznego. Med Pr 1990, 41, 152-158.
• 26. Tsao DA, Yu HS, Cheng JT, Ho CK, Chang HR: The change of beta-adrenergic system in lead-induced hypertension. Toxicol Appl Pharmacol 2000,164, 127-133.
• 27. Vaziri ND, Ding Y: Effect of lead on nitric oxide synthase expression in coronary endothelial cells: role of superoxide. Hypertension 2001, 37, 223-226.
• 28. Ye XB, Fu H, Zhu JL, Ni WM, Lu YW, Kuang XY, Yang SL, Shu BX: A study on oxidative stress in lead-exposed workers. J Toxicol Environ Health A 1999, 57, 161-172.