Developmental expression of SNAP-25 protein in the rat striatum and cerebral cortex

• Autorzy: Sidor-Kaczmarek J , Labuda C. , Litwinowicz B. , Spodnik J.H. , Kowianski P. , Dziewiatkowski J. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

The developmental changes of 25-kDa synaptosomal-associated protein (SNAP-25) expression in the rat striatum and cerebral cortex were examined using Western-blotting and densitometric scanning of immunoblots. Analysis of the striatum extracts from postnatal day 0 (P0) to postnatal day 120 (P120) demonstrated that SNAP-25 is poorly expressed until P14. From this point the expression level gradually increases to reach a maximum on P60 and then decreases. The pattern of SNAP-25 expression in the rat cerebral cortex is different. Two peaks are observed, the first on P10 and the second on P60, after which the expression level decreases. These results appear to confirm the role of SNAP-25 protein in axon outgrowth and synaptogenesis in the nervous system.

Słowa kluczowe

EN

striatum; cerebral cortex; synaptosomal-associated protein; development; immunoblotting technique; protein expression; rat

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2004
• Tom: 63
• Numer: 3
• Opis fizyczny: p.285-288,fig.,ref.

Twórcy

autor

Sidor-Kaczmarek J

• Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland

autor

Labuda C.

autor

Litwinowicz B.

autor

Spodnik J.H.

autor

Kowianski P.

autor

Dziewiatkowski J.

autor

Morys J.

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