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2007 | 48 | 2 |

Tytuł artykułu

Low incidence of bovine leukocyte adhesion deficiency [BLAD] carriers in Indian cattle and buffalo breeds

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
BLAD is an autosomal recessive genetic disease that affects Holstein-Friesian (HF) cattle worldwide. It is a disease characterized by a reduced expression of the adhesion molecules on neutrophils. The disease is caused by a mutation that replaces adenine at 383 with guanine, which causes an amino acid change from aspartic acid to glycine. Blood samples and a few semen samples were collected from 1250 phenotypically normal individuals, including HF (N = 377), HF crossbred (N = 334), Jersey (105), other breeds of cattle (N = 160) and water buffalo Bubalus bubalis (N=274) belonging to various artificial insemination stations, bull mother farms (BMFs) and embryo transfer (ET) centres across the country. PCR-RFLP was performed to detect a point mutation in CD18, surface molecules of neutrophils. The results indicate that out of 1250 cattle and buffaloes tested for BLAD, 13 HF purebreds out of 377 and 10 HF crossbreds out of 334 appear to be BLAD carriers. In the HF and HF crossbred population, the percentage of BLAD carriers was estimated as 3.23%. The condition is alarming as the mutant gene has already entered the HF crossbred cattle population and therefore, the population of HF and its crossbreds needs regular screening to avoid the risk of spreading BLAD in the breeding cattle population of India.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

48

Numer

2

Opis fizyczny

p.153-155,ref.

Twórcy

autor
  • R&D-Biotechnology, National Dairy Development Board, Anand-388 001, Gujarat, India
autor
  • R&D-Biotechnology, National Dairy Development Board, Anand-388 001, Gujarat, India
autor
  • R&D-Biotechnology, National Dairy Development Board, Anand-388 001, Gujarat, India
autor
  • R&D-Biotechnology, National Dairy Development Board, Anand-388 001, Gujarat, India
  • Centre for Biotechnology, Acharya Nagarjuna University, Nagarjunanagar, India

Bibliografia

  • Czarnik U, Kaminski S, 1997. Detection of intronic sequence in the bovine ITGB2 gene. Anim Genet 28: 320-321.
  • Esmaelizad M, Asadzadeh N, Molasalehi M, Hashemnejad-Kh, 2002. Molecular characterization of CD18 gene and identification of BLAD carrier bulls in Iran. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, Montepellier, France: 1-3.
  • Huang YC, Chang HL, Lin DY, Liaw RB, et al. 2000. Gene frequencies of Bovine Leukocyte Adhesion Deficiency of Holstein in Taiwan. J Taiwan Livest Res 33: 37-47.
  • Lee YK, Chang KM, Nam IS, Chang WK, Tak JY, Kim KN, 2002. Studies on the detections of congenital genetic disorder in Holstein proven and candidate bulls. J Anim Sci Tech 44: 279-288.
  • Lien S, Rogne S, Brovold MJ, Alestrom P, 1990. A method of isolation of DNA from frozen (A.I.) bull semen. J Anim Breed Genet 107: 74.
  • Llambi S, Guevara K, Rincon G, Zaffaroni R, Torres E-de, Barrera J, et al. 2003. Frequency of leukocyte adhesion deficiency in a population of Holstein-Friesian cattle in Uruguay. ARS Veterinaria 19: 52-56.
  • Lubieniecki K, Grzybowski G, Lukaszewicz M, Lubieniecka J, 1999. Association between the presence of allele BL in the genome of dairy cows and their productivity. Anim Sci Pap Rep 17: 189-194.
  • Nagahata H, Hagiwara K, Kasamatsu M, Higuchi H, Kurosawa T, 2002. Cytokine profile of a Holstein calf with bovine leukocyte adhesion deficiency during the acute-phase inflammatory response. J Vet Med Sci 64: 1141-1143.
  • Nagahata H, Noda H, Takahashi K, Kurosawa T, Sonoda M, 1987. Bovine granulocytopathy syndrome: Neutrophil dysfunction in Holstein Friesian calves. Zentralbl Veterinarmed A 34: 445-451.
  • Padeeri M, Vijaykumar K, Grupe S, Pratp Narayan M, Schwerin M, Hitesch Kumar M, 1999. Incidence of hereditary citrullinemia and bovine leucocyte adhesion deficiency syndrome in Indian dairy cattle (Bos taurus, Bos indicus) and buffalo (Bubalus bubalis) population. Arch Tierz 42: 347-352.
  • Pareek CS, Kamiński S, 1996. Bovine leukocyte adhesion deficiency (BLAD) and its worldwide prevalence. J Appl Genet 37: 299-311.
  • Ribeiro LA, Baron EE, Martinez ML, Coutinho LL, 2000. PCR screening and allele frequency estimation of bovine leukocyte adhesion deficiency in Holstein and Gir cattle in Brazil. Genet Mol Biol 23: 831-834.
  • Sambrook J, Fritsch EF, Maniatis T, 1989. Molecular cloning: A laboratory Manual, 2nd ed., Vol. 3, Cold Spring, Harbour Laboratory Press, New York.
  • Shuster DE, Kehrli ME, Ackermann Jr MR, Gilbert RO, 1992. Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. Proc Natl Acad Sci 89: 9225-9229.
  • Snoj T, Majdic G, 2003. Bovine leukocyte adhesion deficiency (BLAD) in Slovenian population of Holstein-Friesian bulls. Veterinarske Novice 29: 445-448.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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