Cut-off phenomenon

• Autorzy: Sarapuk J. , Kubica K.
• Języki publikacji: EN

Abstrakty

EN

The change of biological activity of amphiphilic biocides following the change of their hydrophobic parts (the cut-off effect) is discussed. The mechanism of the interaction (between such amphiphiles and model and biological membranes is proposed that explains the cut-off phenomenon. It is proposed, on the basis of experimental studies and theoretical calculations, that the diminished biological activity of amphiphilic compounds upon elongation of thier hydrophobic part can be the result of the appearance of interdigitated structures in the lipid bilayers. On the other hand, weak hydrophobic interactions between amphiphilic compounds of short hydrophobic chins and lipid molecules of model membranes are responsible for the poor biological activity of these compounds.

Słowa kluczowe

EN

amphiphilic compound; biological activity; interdigitation; cut-off phenomenon; biological membrane; interaction; model membrane; lipid molecule; cut-off effect

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 1998
• Tom: 03
• Numer: 3
• Opis fizyczny: p.261-269,fig.

Twórcy

autor

Sarapuk J.

• Agricultural University, 50-375 Wroclaw, Norwida 25, Poland

autor

Kubica K.

Bibliografia

• 1. Witek, S., Grobelny, D., Ptaszkowska, J., Bielecki, A., Bakuniak, E., Fulde, S. and Gorska-Poczopko, J. Belg. Pat. No. 864781, 1978a.
• 2. Witek, S., Oświęcimska, M., Ptaszkowska, J., Bakuniak, E., Gorska-Poczopko, J. and Łaszcz, E. Belg. Pat. No. 864782, (1978b).
• 3. Rucka, M., Oświęcimska, M. and Witek, S. Env. Protection Eng. 7 (1981) 45-55.
• 4. Rucka, M., Oświęcimska, M. and Witek, S. Env. Protection Eng. 9 (1983) 25-30.
• 5. Skala, J., Orlowska-Matuszewska, G., Misiewicz, M., Oswiecimska M., Witek, S. and Kotylak, Z. Acta Microbiol. Polonica 37 (1988) 271-280.
• 6. Devinsky, F. Acta Facult. Pharmac. XXXIX (1985) 197-215.
• 7. Devinsky, F., Masarova, L., Lacko, I. and Mlynarcik, D. Coll. Czechoslovak Chem. Commun. 49 (1984) 2819-2827.
• 8. Devinsky, F., Bittererova, F., Lacko, I. and Mlynarcik, D. Chem. Papers 39 (1985) 125-134.
• 9. Devinsky, F., Lacko, I., Vidlakova, J. and Gallayova, D. Ceskoslovenska Farmacie XXXVI (1987) 141-144.
• 10. Devinsky, F., Kopecka-Leitmanova, A., Sersen, F. and Balgavy, P. J. Pharm. Pharmacol. 42 (1990) 790-794.
• 11. Devinsky, F., Lacko, I., Mlynarcik, D., Svajdlenka, E. and Masarova, L. Acta Facult. Pharmac. XLIV (1990) 127-142.
• 12. Uhrikova, D., Cherezov, V., Yaradaikin, S. and Balgavy, P. Pharmazie 48 (1993) 446-450.
• 13. Cibula, J., Gallova, J., Uhrikova, D. and Balgavy, P. Ceska a Slovenska Farmacie XLIII (1994) 87-91.
• 14. Balgavy, P. and Devinsky, F. XIIth School on Biophysics of Membrane Transport, Zakopane, Poland, School Proceedings (Eds. Przestalski, S., Kuczera, J., Kleszczyńska, H.), part I, 1994, 21-68.
• 15. Kleszczynska, H., Matyjasik, S., Przestalski, S. and Witek, S. Studia Biophysica 84 (1981) 123-132.
• 16. Przestalski, S. and Kuczera, J. Polish. J. Environ. Studies 2 (1992) 13-22.
• 17. Sarapuk, J., Gabrielska, J. and Przestalski, S. Polish J. Environ. Studies 1 (1992) 27-29.
• 18. Otten, D. and Beyer, K. Chem. Phys. Lipids 77 (1995) 203-215.
• 19. Pink, D. A., Green, T. J. and Chapman, D. Biochemistry 19 (1980) 349-356.
• 20. Kubica, K. Cell. Mol. Biol. Lett. 2 (1997) 257-263.
• 21. Stankowski, S. Biophys. J. 60 (1991) 341-351.
• 22. Mouritsen, O. G., Boothroyd, A., Harris, R., Jan, N., Lookman, T., Macdonald, L., Pink, D. and Zuckerman, M. J. Chem. Phys. 79 (1983) 2027-2041.
• 23. Flewelling, R. F. and Hubbell, W. L. Biophys. J. 49 (1986) 541-552.
• 24. White, S. H. and Wiener, M. C. Permeability and stability of lipid bilayers (Ed. E. A. Disalvo, S. A. Simon), CRC Press, Boca Raton, Ann Arbor, London, Tokyo, 1995, pp. 1-19.
• 25. Komatsu, H. and Okada, S. Chem. Phys. Lipids 85 (1997) 67-74.
• 26. Gennis, R. B. Biomembranes. Molecular structures and function. (Ed. C. R. Cantor), Springer Verlag, New York, Berlin, Heidelberg, London, Paris, Tokio, p. 40.
• 27. Vierl, U., Lobbecke, L., Nagel, N. and Cevc, G. Biophys. J. 67 (1994) 1067-1079.
• 28. Nagel, N. E., Cevc, G. and Kirchner, S. Biochim. Biophys. Acta 1111 (1992) 263-269.
• 29. Lobbecke, L. and Cevc, G. Biochim. Biophys. Acta 1237 (1995) 59-69.
• 30. Kinoshita, K., Asano, T. and Yamazaki, M. Chem. Phys. Lipids 85 (1997) 53-65.
• 31. Komatsu, H. and Okada, S. Biochim. Biophys. Acta 1237 (1995) 169-175.