Oddzialywanie przeciwwirusowe oraz cytotoksycznosc nowych pochodnych naturalnych seskwiterpenow i taksolu

• Autorzy: Krawczyk E. , Luczak M. , Majewska A.

Warianty tytułu

EN

Antiviral and cytotoxic activities of new derivatives of natural sesquiterpenes and taxol

• Języki publikacji: PL

Abstrakty

PL

W badaniach prowadzonych uprzednio w Katedrze i Zakładzie Mikrobiologii Lekarskiej stwierdzono, że niektóre pochodne naturalnych seskwiterpenów oraz taksolu wykazywały aktywność przeciwwirusową, hamując namnażanie wirusa HSV-1 in vitro. Celem niniejszej pracy było uzyskanie wglądu w przeciwwirusową i przeciwbakteryjną aktywność siedmiu nowo zsyntety- zowanych związków chemicznych tej grupy.

EN

Common occurrences of serious viral infections and a small number of available antiviral chemotherapeutics necessitate research for new, biologically active substances, which might be of use as antiviral drugs. Natural compounds, e.g., derived from plants and fungi, which show significant and various biological activities, may be a source of potential drugs. Sesquiterpenes, as well as taxol, and their derivatives, may serve as an example. The aim of the present study was to investigate the antiviral, antibacterial and cytotoxic properties of 7 new compounds: derivatives of sesquiterpenes of Lactarius mushroom origin and taxol - JV-benzoylphenylisoserinates of sesquiterpenoid alcohols. The cytotoxicity of the tested compounds against Vero, RD, LLC-MK2 and AJ49 cell lines were assessed using the formazan method. All compounds showed a lower cytotoxicity than taxol. Their antiviral activity in vitro was evaluated by assessing the reduction of virus titre in cells subjected to the compounds in comparison to the cells, which were not subjected to them. It was found that out of 7 investigated compounds 3 exhibited antiviral activity. These compounds inhibited replication of HSV-1 virus in Vero cells. It appears therefore that further investigation of these groups of compounds and their derivatives is justified because they may constitute a potential source of chemotherapeutics.

Słowa kluczowe

PL

wirus HSV-1; aktywnosc antybakteryjna; aktywnosc przeciwwirusowa; cytotoksycznosc; seskwiterpeny; taksol; namnazanie wirusow; hamowanie

• Wydawca: -
• Czasopismo: Medycyna Doświadczalna i Mikrobiologia
• Rocznik: 2005
• Tom: 57
• Numer: 1
• Opis fizyczny: s.93-99,rys.,tab.,bibliogr.

Twórcy

autor

Krawczyk E.

• Akademia Medyczna w Warszawie, ul.T.Chalubinskiego 5, 02-004 Warszawa

autor

Luczak M.

autor

Majewska A.

Bibliografia

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