On the strategy of using nonviral carriers in cancer gene therapy

• Autorzy: Sochanik A. , Szala S.
• Języki publikacji: EN

Abstrakty

EN

Effectiveness and mode of therapeutic gene delivery in vivo as well as biological safety of such transfer must be improved before widespread application of gene therapy in the clinic becomes possible. Most research has so far focused on recombinant viral delivery systems. Clinical future seems to belong, however, to nonviral delivery systems. Such systems feature DNA complexed to lipid, protein, peptide or polymeric carriers with ligands allowing in vivo tissue targeting by the complex and nuclear translocation of the exogene. Nonviral gene carrier systems are discussed together with strategies of destroying cancer cells.

Słowa kluczowe

EN

gene therapy; exogene; gene carrier system; liposome; nonviral carrier; peptide; lipid; nonviral delivery system; protein; viral delivery system; cancer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 2
• Opis fizyczny: p.293-300,fig.

Twórcy

autor

Sochanik A.

• Institute of Oncology, Wybrzeze Armii Krajowej 15, 44-100 Gliwice, Poland

autor

Szala S.

Bibliografia

• 1. Mulligan, R.C. (1993) The basic science of gene therapy. Science 260,926-932.
• 2. Hodgson, C.P. (1995) The vector void in gene therapy. Biotechrwl. 13, 222-225.
• 3. Hirschowitz, E.A., Ohwada, A., Pascal, W.R., Russi, T.J. & Crystal, R.G. (1995) In vivo adcnovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum. Gene Ther. 6, 1055-1063.
• 4. Singhal, A. & Iluang, L (1994) Gene transfer in mammalian cells using liposomes as carriers; in Gene Therapeutics: Methods and Applications of Direct Gene Transfer (Wolff, A .J., ed.) pp. 118-142, Birkhauser, Boston.
• 5. Frese, J., Jr., Wu, C.H. & Wu, G.Y. (1994) Targeting of genes to the liver with glycoprotein carriers. Adv. Drug Deliv. Rev. 14,137-152.
• 6. Wagner, E., Curiel, D. & Cotten, M. (1994) Deli­very of drugs, proteins and genes into cells using transferrin as a ligand for receptor- -mediated endocytosis. Adv. Drug Deliv. Rev. 14, 113-135.
• 7. Monsigny, M. & Roche, A.C. (1994) Glyco- conjugates as carriers for specific delivery of therapeutic drugs and genes. Adv. Drug Deliv. Rev. 14,1-24.
• 8. Remy, JS., Kichler, A., Mordvinov, V., Schuber, F. & Behr, J.P. (1995) Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: A stage toward artificial viruses. Proc. Natl. Acad. Sci. U.S.A. 92,1744-1748.
• 9. Michael, S.I. & Curiel, D.T. (1994) Strategies to achieve targeted gene delivery via the receptor- -mediated endocytosis pathway. Gene Ther. 1, 223-232.
• 10. Ledley, F.D. (1995) Nonviral gene therapy: The promise of genes as pharmaceutical products. Hum. Gene Ther. 6,1129-1144.
• 11. Behr, J.P. (1994) Gene transfer with synthetic cationic amphiphiles: prospects for gene thera­py. Bioconjugate Chem. 5,382-389.
• 12. Oku, N. & Namba, Y. (1994) Long-circulating liposomes. Crit. Rev. Ther. Drug Carrier Syst. 11, 231-270.
• 13. Woodle,M. (1995)Sterically stabilized liposome therapeutics. Adv. Drug Deliv. Rev. 16, 249-265.
• 14. Zalipsky,S. (1995) Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates. Bioconjugate Cheni. 6,150-165.
• 15. Batra, R.K., Wang-Johanning, F., Wagner, E., Carver, R.I., Jr. & Curiel, D. (1994) Receptor- -mediated gene delivery employing lectin- -binding specificity. Gene Ther. 1,255-260.
• 16. Farhood, H., Gao, X., Son, K., Yang, Y.-Y., Lazo, JS. & Huang, L. (1994) Cationic liposomes for direct gene transfer in therapy of cancer and other diseases. Ann. N.Y. Acad. Sci. 716,23-35.
• 17. Plautz, G.E., Nabel, E.G., Fox, B., Yang, Z.-Y., Jaffe, M., Gordon, D., Chang, A. & Nabel, G.J. (1994) Direct gene transfer for the under­standing and treatment of human disease. Ann. N.Y. Acad. Sci. 716,144-153.
• 18. Feigner, J.H., Kumar, R., Sridhar, C.N., Wheeler, C.J., Tsai, Y.J., Border, R., Ramsey, P., Martin, M. & Feigner, P.L (1994) Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. /. Biol. Chem. 269, 2550-2561.
• 19. Plautz, G.E., Yang, Z.Y., Wu, B.Y., Gao, X., Huang, L. & Nabel, G.J. (1993) Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc. Natl. Acad. Sci. U.S.A. 90, 4645- 4649.
• 20. Nabel, G.J., Nabel, E.G., Yang, Z.Y., Fox, B.A., Plautz, G.E., Gao, X., I Iuang, L., Shu, S., Gordon, D. & Chang, A.E. (1993) Direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. U.S.A. 90, 11307-11311.
• 21. Stribling, R., Brunette, F.., IJggitt, D., Gaensler, K. & Debs, R. (1992) Aerosol gene delivery in vivo. Proc. Natl. Acad. Sci. U.S.A. 89,11277-11281.
• 22. Plautz, G.E., Nabel, E.G. & Nabel, G.J. (1994) Direct gene transfer and catheter based gene delivery systems: Applications to cardio­vascular diseases and malignancy; in Gene Therapeutics: Methods and Applications of Direct Gene Transfer (Wolff, J.A., ed.) pp. 303-319, Birkhauser, Boston.
• 23. Feigner, P.L., Gadek, T.R., Holm, M., Roman, R., Chan, H.W., Wenz, M., Northrop, J.P., Ringold, G.M. & Danielsen, M. (1987) Lipofection: A highly efficient, lipid-mediated DNA-transfec- tion procedure. Proc. Natl. Acad. Sci. U.S.A. 84, 7413-7417.
• 24. Gao, X. & Huang, L (1991) A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem. Biophys. Res. Com- tnun. 179,280-285.
• 25. Rose,)., Buonocore, L. & Whitt, M.A. (1991) A new cationic liposome reagent mediating nearly quantitative transfection of animal cells. Bio- techniques 10,520-525.
• 26. Missol, E., Sochanik, A. & Szala, S. (1995) Introduction of murine D-4 gene into B16(F10) melanoma tumors by direct gene transfer with DNA-liposome complexes. Cancer Lett. 97, 189-193.
• 27. Puyal, C., Milhaud, P., Bienvenue, A. & Philippot, J.R. (1995) A new cationic liposome encapsulating genetic material. A potential delivery system for polynucleotides F.ur. ). Biochem. 228,697-703.
• 28. Perales,J.C., Ferkol,T., Beegen, H., Ratnoff, O.D. & Hanson, R.W. (1994) Gene transfer in vivo: Sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc. Natl. Acad. Sci. U.S.A. 91, 4086- 4090.
• 29. Behr, J.-P., Demeneix, B., Loeffler, J.P. & Mutul, J.P. (1989) Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc. Natl. Acad. Sci. U.S.A. 86,6982-6986.
• 30. Hawley-Nelson, P., Ciccarone, V., Gebeyehu, G. & Jesse, J. (1993) LipofectAMINE™ reagent: A new, higher efficiency polycationic liposome transfection reagent. Focus 15,73-78.
• 31. Wu, G.Y. & Wu, C.H. (1987) Receptor-mediated in vitro gene transformation by a soluble DNA carrier system. /. Biol. Chem. 262,4429^4432.
• 32. Wu, G.Y. & Wu, C.H. (1987) Receptor-mediated gene delivery and expression in vivo. J. Biol. Chan. 263,14621-14624.
• 33. Chen, J., Stickles, R.J. & Daichendt, K.A. (1994) Galactosyl ted histone-mediated gene transfer and expression. Hum. Gene Ther. 5,429-435.
• 34. Wagner, E., Zenke, M., Cotten, M., Beug, H. & Birnstiel, M.L. (1990) Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci. U.S.A. 87,3410-3414.
• 35. Rosenkranz, A.A., Yachmenev, S.V., Jans, D.A., Serebryakova, N.V., Murav'ev, V.I., Peters, R. & Sobolev, A. (1992) Receptor-mediated endo- cytosis and nuclear transport of a transfecting DNA construct Exp. Cell Res. 199,323-329.
• 36. Lee, R.J. & Low, P.S. (1994) Delivery of liposomes into cultured KB cells via folate receptor- -mediated endocytosis. J. Biol. Chem. 269, 3198-3204.
• 37. Ross, G.F., Morris, R.E., Ciraolo, G., Huelsman, K., Bruno, M., Whitsett, J.A., Baatz, J.F.. & Korfhagen, T.R. (1995) Surfactant protein A-poIylysine conjugates for delivery of DNA to airway cells in culture. Hum. Gene Ther. 6,31-40.
• 38. Mullen, C.A., Kilstrup, M. & Blaese, R.M. (1992) Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: A negative selection system. Proc. Natl. Acad. Sci. U.S.A. 89, 33-37.
• 39. Bridgewater, J.A., Springer, C.J., Knox, R.J. & Collins, M.K.L. (1995) VDEPT using a novel prodrug enzyme system demonstrates cytotoxicity to murine and human cell lines in vitro. 3rd Symposium on Gene Therapy. P 9, Berlin-Buch, Germany.
• 40. Moolten, F. (1986) Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res. 46, 5276-5281.
• 41. Sorscher, E.J., Peng, S., Bebok, Z., Allan, P.W., Bennett, LB., Jr. & Parker, W.B. (1994) Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines. Gene Ther. 1,233-238.
• 42. Lanzavechchia, A. (1993) Identifying strategics for immune intervention. Science 260,937-944.1. 43. Colombo. M.R fc Horni.Ci.t 1994) C vtokineeene transfer in tumor inhibition and tumor therapy: Where are we now? Immunol. Today 15,48-51.
• 44. Bruyns, C, Gerard, C. & Velu, T. (1994) Cancer escape from immune surveillance: How can it be overcome by gene transfer? Eur. J. Cancer 30A, 1176-1181.
• 45. Blankenstein, T. (1994) Increasing tumor immu- nogenicity by genetic modification. Eur. J. Cancer 30A, 1182-1187.
• 46. Trubetskoy, V.S., Torchilin, V.P., Kennel, S. & Huang, L (1992) Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly- (L-lysine)-antibody conjugate in mouse lung endothelial cells. Biochim. Biophys. Acta 1131, 311-313.
• 47. Nassander, U.K., Steerenberg, P.A., De Jong, W.I I., Van Overveld, W.O.W.M., Boekhorst, C.M.E., Poels, L.G., Jap, P.H.K. & Storm, G. (1995) Design of immunoliposomes directed against human ovarian carcinoma. Biochim. Biophys. Acta 1235,126-139.