The slow sarco-endoplasmic reticulum Ca2plus-ATPase declines independently of slow myosin in soleus muscle of diabetic rats

• Autorzy: Racz G. , Szabo A. , Ver A. , Zador E.
• Języki publikacji: EN

Abstrakty

EN

 The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions. In the streptozotocin-induced diabetes of rats (stz-rats), the soleus muscle showed peripheral neuropathy and the SERCA2a level decreased in type I (slow-oxidative) fibers compared to the control muscles, whereas the expression of the corresponding slow MyHC1 did not change. No difference was found at the mRNA and protein levels of SERCA and MyHC isoforms in the whole soleus, except that the level of the SERCA2a protein specifically declined in stz-rats compared to the controls. This shows that the coordinated expression of SERCA2a and MyHC1 is disrupted at the SERCA2a protein level in the diabetic soleus. The results are in line with previous observations that regulators of the Ca-homeostasis may adapt faster to type I diabetes than the contractile elements.

Słowa kluczowe

PL

sarcoplasmic reticulum; calcium; ATPase decline; slow myosin; myosin; soleus muscle; rat; diabetes; muscle fibre; myosin heavy chain; isoform; skeletal muscle; pathological condition; neuropathy; homeostasis

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2009
• Tom: 56
• Numer: 3
• Opis fizyczny: p.487-493,fig.,ref.

Twórcy

autor

Racz G.

• University of Szeged, Szeged, Dom ter 9, H-6720 Hungary

autor

Szabo A.

autor

Ver A.

autor

Zador E.

Bibliografia

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