Locusts as models for studying brain diseases and behaviour

• Autorzy: Goldsworthy G.J. , Khan N.A.
• Języki publikacji: EN

Abstrakty

EN

Two examples illustrate the use of locusts as models for the study of brain disease and behaviour. First, immune challenge induces sickness behaviour in locusts: immune challenge with laminarin induces anorexia, paralleling phenomena seen in other animals including mammals. Laminarin-induced anorexia in locusts can be blocked by Mianserin, suggesting the involvement of serotonergic receptors. Second, the blood-brain barrier in locusts can be used to study virulence factors in Escherichia coli K1, one of the causative agents of bacterial meningitis in humans: two of the known virulence determinants in mammals, OmpA and CNF1, are also essential for invasion of the locust CNS.

Słowa kluczowe

EN

blood-brain barrier; brain disease; sickness-induced anorexia; locust; pathogenicity; Escherichia coli; mammal; Locusta migratoria; African migratory locust; model; behaviour

• Wydawca: -
• Czasopismo: Pestycydy
• Rocznik: 2007
• Numer: 3-4
• Opis fizyczny: p.5-10,fig.,ref.

Twórcy

autor

Goldsworthy G.J.

• Birkbeck College, Malet Street, London WC1E 7HX, U.K.

autor

Khan N.A.

Bibliografia

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