Podstawy immunologii przewodu pokarmowego

• Autorzy: Romanski K

Warianty tytułu

EN

Principles of gastrointestinal immunology

• Języki publikacji: PL

Abstrakty

EN

Beside the variety of environmental and neurohormonal factors regulating the gastrointestinal function, microbes and parasites can also modulate this function. Their influences can be harmful, thus the gastrointestinal tract is equipped with numerous specific or unspecific defense mechanisms. While the gastric acid secretion in the stomach, gastrointestinal mucosal continuity, or some adaptation mechanisms are unspecific ones, the immunological gastrointestinal system comprises a cluster of specific defense mechanisms. The identification, binding and neutralization of the aforementioned antigens serves as its principal role. The immunological system is well developed in the gastrointestinal tract and might be understood as the main barrier protecting the organism against the infectious factors. The gastrointestinal immunological system is localized mainly in subepithelial space, where the lymphocytes and a substantial amount of immunoglobulin A are present. Secretory immunoglobulin A also occurs in the intestinal lumen and is able to block the adhesion of antigen proteins to intestinal epithelium. However, the portion of antigens passing the gut epithelium migrating into the subepithelial space where it is neutralized, at least in part, can spread over the body in at least three different pathways: to Peyer patches and then toward the mesenterical lymph nodes and finally to a lymph, directly to the lymphatic vessels of intestinal villus or to the mesenteric veins. In addition, the antigens evoke various immunological reactions. Gastrointestinal immunological processes can be amplified (sensitization) or hampered (tolerance). The nervous system can also participate in immunological reactions linked with the gastrointestinal tract. Thus, in the gastrointestinal tract and also in the nervous system exist clear relationships between their basic functions and immunological processes.

Słowa kluczowe

PL

odpowiedz immunologiczna; jelita; fizjologia zwierzat; przewod pokarmowy; bariery mechaniczne; procesy immunologiczne; immunologia

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 07
• Opis fizyczny: s.768-772,rys.,bibliogr.

Twórcy

autor

Romanski K

• Akademia Rolnicza we Wroclawiu, ul.Norwida 31, 50-375 Wroclaw

Bibliografia

• 1.Ahuja V., Dieckgraefe B. K., Anant S.: Molecular biology of the small intestine. Curr. Opin. Gastroenterol. 2006, 22, 90-94.
• 2.Backert S., Konig W.: Interplay of bacterial toxins with host defence: molecular mechanisms of immunomodulatory signalling. Int. J. Med. Microbiol. 2005, 295, 519-530.
• 3.Bailey M., Haverson K.: The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals. Vet. Res. 2006, 37, 443- -453.
• 4.Chadwick R. W., George S. E., Claxton L. D.: Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens. Drug Metab. Rev. 1992, 24, 425-492.
• 5.Dowling R. H.: Intestinal adaptation and its mechanisms, [w:] Jewell D. P., Selby W. S. (wyd.): Topics in Gastroenterology. Blackwell Scientific Publications 1982, 135-156.
• 6.Ekblad E., Ekelund M., Sundler F.: Neuronal plasticity in intestinal adaptation, [w:] Kramer H. J., Singer M. V. (wyd.): Neurogastroenterology. From the Basics to the Clinics. Kluwer Academic Publishers, Dordrecht 2000, 33-43.
• 7.Elphick D. A., Mahida Y. R.: Paneth cells: their role in innate immunity and inflammatory disease. Gut 2005, 54, 1802-1809.
• 8.Fasano A., Shea-Donohue T.: Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat. Clin. Pract. Gastroenterol. Hepatol. 2005, 2, 416-422.
• 9.Frieling T., Weber E., Schemann M.: Neuroimmune interactions: alarm programs as a defence mechanism, [w:] Kramer H. J., Singer M. V. (wyd.): Neurogastroenterology. From the Basics to the Clinics. Kluwer Academic Publishers, Dordrecht 2000, 577-588.
• 10.Guarner F.: Enteric flora in health and disease. Digestion 2006, suppl. 1, 5-12.
• 11.Haller D.: Intestinal epithelial cell signalling and host-derived negative regulators under chronic inflammation: to be or not to be activated determines the balance towards commensal bacteria. Neurogastroenterol. Motil. 2006, 18, 184-199.
• 12.Hanauer S. B., Kraft S. C.: Intestinal immunology, [w:] Berk J. E. (wyd.): Bockus Gastroenterology. Saunders W. B. Company, Philadelphia 1985, 1607-1631.
• 13.Hirsh D. C.: Microflora, mucosa, and immunity, [w:] Anderson N. V. (wyd.): Veterinary Gastroenterology. Lea&Febiger, Philadelphia 1980, s. 199-219.
• 14.Lasek W.: Układ odpornościowy związany z błonami śluzowymi, [w:] Gołąb J., Jakóbisiak M., Lasek W. (wyd.): Immunologia., PWN, Warszawa 2002, 288-302.
• 15.Laukoetter M. G., Bruewer M., Nusrat A. L.: Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr. Opin. Gastroenterol. 2006, 22, 85-89.
• 16.Lundgren O.: Interface between the intestinal environment and the nervous system. Gut 2004, 53, suppl. 2, 16-21.
• 17.Macpherson A. J., Geuking M. B., McCoy K. D.: Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology 2005, 115, 153-162.
• 18.Marth T., Zeitz M.: The intestinal immune system, [w:] Blum H. E., Bode C., Bode J. C., Sartor R. B. (wyd.): Gut and the Liver. Kluwer Academic Publishers, Dordrecht 1998, 12-27.
• 19.Melichar B., Dvorak J., Hyspler R., Zadak Z.: Intestinal permeability in the assessment of intestinal toxicity of cytotoxic agents. Chemotherapy 2005, 51, 336-338.
• 20.Niuwenhuijs V. B., Verheem A., van Duijvenbode-Bermer H., Visser M. R., Verhoef J., Gooszen H. G., Akkermans L. M. A.: The role of interdigestive small bowel motility in the regulation of gut microflora, bacterial overgrowth, and bacterial translocation in rats. Ann. Surg. 1998, 228, 188-193.
• 21.Onderdonk A. B.: Intestinal microflora: control and overgrowth, [w:] Blum H. E., Bode C., Bode J. C., Sartor R. B. (wyd.): Gut and the Liver. Kluwer Academic Publishers, Dordrecht 1998, 3-11.
• 22.Oswald I. P.: Role of intestinal epithelial cells in the innate immune defence of the pig intestine. Vet. Res. 2006, 37, 359-368.
• 23.Ouellette A. J., Selsted M. E.: Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J. 1996, 10, 1280-1289.
• 24.Shen L., Turner J. R.: Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. Am. J. Physiol. 2006, 290, G577-G582.
• 25.Stevens C. E., Hume I. D.: Contributions of microbes in vertebrate gastrointestinal tract to production and conservation of nutrients. Physiol. Rev. 1998, 78, 393-427.
• 26.Stokes C., Waly N.: Mucosal defence along the gastrointestinal tract of cats and dogs. Vet. Res. 2006, 37, 281-293.
• 27.Theodorou V., Fioramonti J., Bueno L.: Integrative neuroimmunology of the digestive tract. Vet. Res. 1996, 27, 427-442.
• 28.Willard M. D., Leid R. W.: Non-uniform horizontal and vertical distributions of immunoglobulin A in canine intestines. Am. J. Vet. Res. 1981, 42, 1573- -1579.
• 29.Wronowska W., Godlewska R., Jagusztyn-Krynicka E. K.: Wpływ bakteryjnych patogenów układu pokarmowego na szlaki apoptyczne komórek eukariotycznych. Post. Bioch. 2005, 51, 270-279.
• 30.Zasloff M.: Antimicrobial peptides of multicellular organisms. Nature 2002, 415, 389-395.