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1992 | 39 | 3 |
Tytuł artykułu

Enzyme activities in human breast tumours

Autorzy
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The activities of six enzymes associated with carbohydrate metabo­lism were measured both in carcinomas and in normal breast tissues. The following differences were observed. 1. The carcinoma showed higher enzyme activities than the normal nummary tissue. 2. The ratios of glutamate dehydrogenase, hydroxybutyrate dehydrogenase, gluta­thione reductase and catalase to lactate dehydrogenase were lower in carcinomas than in normal tissues. Similarly, the ratios of glutamate dehydrogenase, hydroxybutyrate dehydrogenase, glutathione reduc­tase and catalase to glucose-6-phosphate dehydrogenase were also sig­nificantly lower in carcinomas. 3. There were no significant differences in enzyme activities between I and II stage of the disease and the metastatic tissues, however, there were significant differences between I and III stage. The significance of these findings is discussed in terms of the alterations in the balance between the metabolic pathways.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
39
Numer
3
Opis fizyczny
p.289-294
Twórcy
autor
  • University of M.Curie-Sklodowska, Akademicka 19, 20-033 Lublin, Poland
Bibliografia
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  • 3. Balinsky, D., Platz, C. E. & I.ewis, J. W. (1984)/ Null. Cancer Inst., 72. 217 - 224.
  • 4. Huttcr, R. V. P. (1989) Breast Cancer, 83 - 93.
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  • 8. Recommendations of the German Socicty ft>r Clinical Chemistry (1972) J. Clin Chem. Clin. Biochem., 10, 281 - 291.
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  • 10. Manso. C. & Wróblewski, F. (1958) J. Clin. Invest., 37,214.
  • 11. Pifferri, P. G., Lanzarini, G. & Biancani, M. (1981) Annali di Cliimica, 729 - 733.
  • 12. Hennipman. A , Oirschot, B. A., Smits, J.. Rijkscn. G. & Staal, G. E. J. (1988) Tumor Biol., 9, 241 -248.
  • 13. Spyratos, F.. Oglobine. J. & Dcsplaccs. A. (1986) Eur. J. Cancer. 22,21 - 27.
  • 14. Fortelconi, G.. Argiolas, L., Farris, A., Ferrari*, A. M., Gaeiani, G. F. & Meloni, T. (1988) Tumori, 74,665-667.
  • 15. McDcrmotl, E. W. M., Barron, F.. T., Smyth. P P A. & O'Higgins, N. J. (1990) Brit. J. Surg., 77, 1179 - 1182.
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  • 18. Buckley, B. J., Tanswell, A. K. & Freeman, B. A. (1987) J. Appl. Physiol63, 359 - 367.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-93f3997b-09fc-4c1a-8907-3336bdd6d733
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