The influence of low doses of N-nitrosodimethylamine on the choosen parameters of iron balance in rat

• Autorzy: Roszczenko A. , Jablonski J. , Moniuszko-Jakoniuk J. , Jurczuk M. , Brzoska M.
• Języki publikacji: EN

Abstrakty

EN

The aim of our work was to study choosen parameters of iron balance after exposure on low concentration of N-nitrosodimethylamine (NDMA). Studies were performed on male Wistar rats of body weight 200 g, which were exposured on NDMA in concentration of 10 μg/dm3, 20 μg/dm3, 50 μg/dm3 in drinking water. The assays of choosen parameters of iron balance (iron concentration in serum, liver and spleen, total and latent serum iron-binding capacity, percentage of transferrin saturation and the concentration of hemoglobin and hematocrit value) were performed after 10, 30 and 90 days of exposure. The exposure of animals on NDMA in concentration of 10μg/dm3 did not evoke significant changes in choosen iron balance parameters. After exposure of rats on NDMA in concentration of 20 μg/dm3 the increasing of hemoglobin concentration in dependence on the time of persisting of exposure was observed. The latent iron-binding capacity was decreased in comparison to the control and the percentage of transferrin saturation was significantly increased in 30-th and 90-th day of the experiment. Iron concentration in spleen was increased in dependence on time of persisting of exposure on NDMA. Other parameters were not changed. The exposure of rats on NDMA in concentration of 50 μg/dm3 caused the decreasing of hematocrit value, hemoglobin concentration and iron concentration in serum. The latent iron-binding capacity and percentage of transferrin saturation significantly decreased in comparison to control group. Iron concentration in liver was increasing after 30 days of exposure, but in spleen it was decreasing after the same time. The exposure of animals on NDMA in concentration of 20 μg/dm3 and 50 μg/dm3 caused disturbances of iron balance in rat organism. These changes were different in dependence on the concentration of NDMA.

Słowa kluczowe

EN

iron; N-nitrosodimethylamine; spleen; carcinogenic activity; blood; liver; rat

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1996
• Tom: 05
• Numer: 5
• Opis fizyczny: p.37-40,ref.

Twórcy

autor

Roszczenko A.

• Medical Academy, Mickiewicza 2c Street, Bialystok, Poland

autor

Jablonski J.

autor

Moniuszko-Jakoniuk J.

autor

Jurczuk M.

autor

Brzoska M.

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