EN
3-hydroxy-3-methylbutyric acid (HMB) in immunological reactions generated by nutritional allergy in guinea pigs The systemic immune responses were examined in pa- renterally milk-sensitized guinea pigs. This type of sensitization simulating alimentary allergy led to positive passive cutaneous anaphylactic (PCA) responses and high IgG titers against beta lactoglobulin (beta-LG). A further increase in IgG titers induced by a dietary supplement of HMB was observed. These results indicate that HMB increases immune responses of parenterally milk-sensitized guinea pigs as expressed by IgG beta-LG antibodies and PCA titers. What concerns the alimentary, this effects is not of an advantage and suggests that HMB - treated animals can be more allergic to food consumption.