The graft-versus-host [GvH] reaction and experimental trichinellosis. II. The effect of Trichinella spiralis on the local GvH reaction in the mouse popliteal lymph node

• Autorzy: Bany J
• Języki publikacji: EN

Abstrakty

EN

Activity of spleen lymphocytes derived from T. spiralis-infected C3H/w mice in the local GvH reaction was assessed using the popliteal lymph node GvH assay. It was found that splenocytes obtained on day 10 of the infection were substantially more active in the reaction than the spleen cells collected from uninfected donors. This effect correlated inversely with the infectious dose of the parasite, i.e. cells obtained from mice infected with 500 larvae per mouse were less efficient stimulators of the GvH reaction than splenocytes isolated from mice infected with 200 larvae per mouse. On day 30 of the infection activity of spleen T cells in the GvH reaction was suppressed in comparison to the control splenocytes but on day 60 post infection this activity returned to the baseline level. The above variations in the activity of splenic T lymphocytes in the local GvH reaction were readily quantitated by comparison of the three appropriate parameters assessed in the popliteal lymph nodes of both the infected and control animals and expressed as the mass, cellularity, and proliferation coefficients, respectively.

Słowa kluczowe

EN

graft-versus-host reaction; mouse; mice; Trichinella spiralis

• Wydawca: -
• Czasopismo: Acta Parasitologica
• Rocznik: 1992
• Tom: 37
• Numer: 2
• Opis fizyczny: p.105-109,fig.,tab.

Twórcy

autor

Bany J

• Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland

Bibliografia

• Bány J. 1992. The graft-versus-host (GvH) reaction and experimental trichinellosis. I. Functional reactivities of T lymphocytes during experimental trichinellosis in irradiated mice developing the GvH reaction. Acta Parasitologica , 37, 99-104.
• Crowle A. J. 1975. Delayed hypersensitivity in the mouse. Advances in Immunology, 20, 197-264.
• Cunningham S. D., Kuhn R. E., Hatcher F. M. 1981. Trypanosoma cruzi: responses by cells from infected mice to alloantigens. Experimental Parasitology, 51, 141-151.
• Ford W. L., Burr W., Simonsen M. 1970. A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation, 10, 258-265.
• Hardt F., Claesson M. H. 1971. Graft-versus-host reactions mediated by spleen cells from amyloidotic and nonamyloidotic mice. Transplantation, 12, 36-39.
• Kozar Z., Kozar M. 1963. The course of experimental trichinellosis in mice. Methods of infection and mortality and weight of animals. Wiadomości Parazytologiczne, 9, 403-409.
• Markwick J. R., Barners R. M., Pegrum G. D. 1977. Allogenic cell interactions in the rat. I. Changes in the cell proliferation during local graft-versus-host and host versus graft reactions. Cellular Immunology, 32, 52-59.
• Monie H. J., Everett N. B. 1974. The popliteal node assay for graft-versus-host interaction in mice. I. Localization and proliferation of donor and host cells within the popliteal node. Anatomical Recoveries,19, 10-26.
• Mosmann T. R., Coffman R. L. 1987. Two types of mouse helper T-cell clone. Implications for immune regulation. Immunology Today, 1, 223-227.
• Pals S. T., Radaszkiewicz T., Gleichman E. 1984. Allosuppressor -and allohelper - T cells in acute and chronic graft-versus-host disease. IV. Activation of donor allosuppressor cells in confined to acute GvH. Journal of Immunology, 132, 1669-1678.
• Piquet P. F., Dewery H. K., Vassali P. 1977. Origin and nature of the cells participating in the popliteal graft-versus-host reaction in mouse and rat. Cellular Immunology, 31, 242-254.
• Rolstad B. 1976. The host component of the graft-versus-host reaction. Transplantation, 21, 117-123.
• Sikorska H., Ryżewski J., Chwaliński S. 1980. Kinetics of suppressor cells induction during the course of local graft-versus-host reaction in rats. International Journal of Tissue Reaction, 2, 67-75.
• Wassom D. L., Dougherty D. A., Krco C. J., David C. S. 1984. H-2-controlled, dose-dependent suppression of the response that expels adult Trichinella spiralis from the small intestine of mice. Immunology, 53, 811-818.