Respiratory effects of capsaicin occur beyond the lung vagi in anaesthetized rats

• Autorzy: Kaczynska K , Szereda-Przestaszewska M.
• Języki publikacji: EN

Abstrakty

EN

The effects of an intravenous capsaicin challenge on the respiratory pattern and ventilation were studied in 15 urethane/chloralose-anaesthetized, spontanously breathing rats. Bolus injection of capsaicin at a dose of 5 |Lig/kg into the right femoral vein evoked respiratory arrest in all animals (both prior to and after bilateral midcervical vagotomy), which effect was abolished by ruthenium red pretreatment. Breathing that followed the apnoea was of enlarged tidal volume and initially increased respiratory rate, which resulted in an augmented ventilation. The capsaicin-induced respiratory changes were independent of vagal integrity and may depend on stimulation of vanilloid receptors within the nodose ganglia.

Słowa kluczowe

EN

vagotomy; vagus nerve; stimulation; capsaicin; blood-brain barrier; ruthenium red; rat; apnea; ventilation; capsaicin receptor; ganglion; respiration; pulmonary chemoreflex

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2000
• Tom: 60
• Numer: 2
• Opis fizyczny: p.159-165,fig.

Twórcy

autor

Kaczynska K

• Polish Academy of Sciences, 5 Pawinski St., 02-106 Warsaw, Poland

autor

Szereda-Przestaszewska M.

Bibliografia

• Brender D., Webb-Peploe M.M. (1969) Vasculary responses to stimulation of pulmonary and carotid baroreceptors by capsaicin. Am. J. Physiol. 217: 1837-1845.
• Chahl L.A., Lynch A.M. (1987) The acute effects of capsaicin on the cardiovascular system. Acta Physiol. Hung. 69:413­419.
• Coleridge H.M., Coleridge J.C.G. (1984) Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev. Physiol. Biochem. Pharmacol. 99: 1­110.
• Coleridge H.M., Coleridge J.C.G. (1994) Pulmonary reflexes: neural mechanisms of pulmonary defense. Annu. Rev. Physiol. 56: 69-91. Coleridge H.M., Coleridge J.C.G., Kidd C. (1964) Role of the pulmonary arterial baroreceptors in the effects produced by capsaicin in the dog. J.Physiol. (London) 170: 272-285.
• Donnerer J., Lambeck F. (1983) Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurons via reflex centre in the brainstem. Naunyn-Schmiedebergs Arch. Pharmacol. 342: 293-295.
• Hedner J., Hedner T., Jonason J. (1985) Capsaicin and regu­lation of respiration: interaction with central substance P mechanisms. J. Neural Transm. 61: 239-252.
• Helliwell R.J.A., McLatchie L.M., Clarke M., Winter J., Bevan S., Mclntyre P. (1998) Capsaicin sensitivity is asso­ciated with the expression of the vanilloid (capsaicin) re­ceptor (VR1) mRNA in adult rat sensory ganglia. Neurosci. Lett. 250: 177-180.
• Holzer P. (1988) Local effector functions of capsaicin-sensi­tive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24: 739-768.
• Jancsó G., Király E. (1980) Distribution of chemosensitive primary afferents in the central nervous system of the rat. J. Comp. Neurol. 190: 781-792.
• Kaczyńska K. (1999) Respiratory effects of capsaicin in the anaesthetized rats. J. Physiol. Pharmacol. 50 (Suppl. 1): 139.
• Kopczyńska B., Szereda-Przestaszewska M. (1998) Apnoeic responses to pulmonary and systemic challenge of cap­saicin in cats. J. Physiol. Pharmacol. 49: 25-35.
• Lee L.Y., Lundberg J.M. (1994) Capsazepine abolishes pul­monary reflexes induced by capsaicin in anaesthetized rats. J. Appl. Physiol. 76: 1848-1855.
• Lou Y. P., Karlsson J.A., Franco-Cereceda A., Lundberg J.M. (1991) Selectivity of ruthenium red in inhibiting broncho- constriction and CGRP release induced by afferent C-fibre activation in the guinea-pig lung. Acta Physiol. Scand. 142: 191-199.
• Makara G.B., Gyorgy L., Molnár J. (1967) Circulatory and respiratory responses to capsaicin, 5-hydroxytryptamine and histamine in rats pretreated with capsaicin. Arch. Int. Pharmacodyn. 170: 39-45.
• Mitchell H.W., Tomlin J., Ward R.J. (1984) Reflex changes in respiration and heart rate evoked by intravenous and left ventricular injection of 5-HT and capsaicin in anaesthet­ized rats: a comparison of mechanisms. Lung 162: 153­163.
• Naida A. M., Ghosh T.K., Mathew O.P. (1996) Airway pro­tective reflexes elicited by laryngeal ammonia: role of C- fiber afferents. Respir. Physiol. 103: 11-17.
• PalećekF., Sant'Ambrogio G., Sant'AmbrogioF.B., Mathew O.P. (1989) Reflex responses to capsaicin: intravenous, aerosol and intratracheal administration. J. Appl. Physiol. 67:428-1437.
• Petho G., Szolcsányi J. (1990) Systemically applied ru­thenium red inhibits the stimulation of sensory recep­tors by capsaicin. Acta Physiol. Hung. 75 (Suppl.): 235-236.
• Pórszász J., Gyorgy L., Pórszász-Gibiszer K. (1955) Cardio­vascular and respiratory effects of capsaicin. Acta Physiol. Hung. 8: 61-76.
• Pórszász J., Such G., Pórszász-Gibiszer K. (1957) Circulatory and respiratory chemoreflex. Acta Physiol. Hung. 12:189­205.
• Reíd J., McCullogh J. (1987) Capsaicin in blood-brain per­meability. Neurosci. Lett. 81: 165-170.
• Saria A., Skofitch G., Lambeck F. (1982) Distribution of cap­saicin in rat tissues after systemic administration. J. Phar­macol. 34: 273-275.
• Sant' Ambrogio G., Sant' Ambrogio F.B.(1997) Reflexes from the upper airway, lungs, chest wall and limbs. In: The lung (Eds. R.E. Crystal and J.B. West). Lippincott-Raven Pub­lishers, Philadelphia, p. 1805-1819.
• Schelegle E.S., Mansoor J.K., Green J.F. (1995) Influence of background vagal C-fiber activity on eupneic breathing pattern in anesthetized dogs. J. Appl. Physiol. 79: 600-606.
• Sekizawa S., Tsubone H. (1994) Nasal receptors responding to noxious chemicals irritants. Respir. Physiol. 96: 37-48.
• Szallasi A., Nilsson S., Farkas-Szallasi T., Blumberg P.M., Hokfelt T., Lundberg J.M. (1995) Vanilloid (capsaicin) re­ceptors in the rat: distribution in the brain, regional dif­ferences in the spinal cord, axonal transport to the periphery and depletion by systemic vanilloid treatment. Brain Res. 703: 175-183.
• Toh C.C., Lee T.S., Kiang A.K. (1955) The pharmacological actions of capsaicin and analogues. Br. J. Pharmacol. 10: 175-182.
• Tsubone H., Sant'Ambrogio G., Anderson J.W., Orani G.P. (1991) Laryngeal afferent activity and reflexes in the gui­nea pig. Respir. Physiol. 86: 215-231.
• Wood J.N., Docherty R. (1997) Chemical activators of sen­sory neurones. Annu. Rev. Physiol. 59: 457-482.