Influence of subtoxic doses of fenitrothion on memory processes, movement activity, and movement coordination in mice exposed to transient oligaemic brain hypoxia

• Autorzy: Nieradko-Iwanicka B , Borzecki A.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to find out if subtoxic doses of fenitrothion (0.1 LD₅₀, LD₅₀ =166.6 mg/kg) administered to mice exposed to transient oligaemic brain hypoxia induced by bilateral clamping of the carotid arteries (BCCA) influence memory processes, movement activity, and coordination. The BCCA was carried out under ketamine + xylazine anaesthesia. Common carotid arteries were clamped for 30 min. Twenty-four hours later; the animals were injected intraperitoneally with 0.1 LD₅₀ of fenitrothion. Controls and sham-operated animals (with carotids separated but not clamped) were injected with respective volumes of bidistilled water. All the animals were trained in passive avoidance (PA) task. The examination of memory retention in PA was done 24 h later followed by testing of fresh spatial memory in a Y- maze, movement co-ordination, and spontaneous movement activity in a 30-min period. Fenitrothion did not significantly alter memory processes in the examined mice. However, the movement coordination was significantly impaired in animals that underwent BCCA alone as well as being oligaemic and under the influence of fenitrothion vs control groups. The same groups demonstrated significantly impaired spontaneous movement activity vs controls.

Słowa kluczowe

EN

fenitrothion; toxicity; memory process; veterinary medicine; mouse; movement coordination; movement activity; mice; hypoxia; animal disease

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2008
• Tom: 52
• Numer: 2
• Opis fizyczny: p.295-298,fig.,ref.

Twórcy

autor

Nieradko-Iwanicka B

• Medical University of Lublin, 20-080 Lublin, Poland

autor

Borzecki A.

Bibliografia

• 1. Allen D.G., Dyson D.H., Pascoe P.J., O'Grady M.R.: Evaluation of a xylazine-ketamine hydrochloride combination in the cat. Can J Vet Res 1986, 50, 23-26.
• 2. Baniadam A., Afshir F.S., Balani M.R.B.: Cardiopulmonary effects of acepromazine-ketamine administration in the sheep. Bull Vet Inst Pulawy 2007, 51, 93-96.
• 3. Barnes C.A.: Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 1979, 93, 74-104.
• 4. Block. F., Sieklucka M., Schmidt-Kastner R., Heim C., Sontag K-H.: Metabolic changes during and after transient clamping of carotid arteries in normotensive rats. Brain Res Bull 1993, 31, 91-96.
• 5. Bortolotto Z.A., Heim C., Sieklucka M., Block F., Sontag K-H., Cavalhiero E.A.: Effect of bilateral clamping carotid arteries on hippocampal kindling in rats. Physiol Behav 1991, 49, 667-671.
• 6. Delatour B., Gisquet-Verrier P.: Prelimbic cortex specific lesions disrupt delayed-variable response tasks in the rat. Behav Neurosci 1996, 110, 1282-1298.
• 7. Harrison F.E., Reiserer R.S., Tomarken A.J., McDonald M.P.: Spatial and nonspatial escape strategies in the Barnes maze. Learn Memory 2006, 13, 809-819.
• 8. Heim C., Sieklucka M., Block F., Schmidt-Kastner R., Jaspers R., Sontag K.-H.:. Transient occlusion of carotid arteries leads to disturbed learning and memory in the rat. In: Pharmacology of Cerebral Ischemia, Ed. by Jriegstein J., Oberpichler- Schwenk, 1990.
• 9. Heyer E.J., DeLaPaz R., Halazun H.J., Rampersad A., Sciacca R., Zurica J., Benvenisty A.I., Quest D.O., Todd G.J., Lavine S., Solomon R.A., Connolly E.S. Jr.: Neuropsychological dysfunction in the absence of structural evidence for cerebral ischemia after uncomplicated carotid endarterectomy. Neurosurgery 2006, 58, 474-480.
• 10. Jóźwiak L., Sieklucka-Dziuba M., Kleinrok Z.: Behavioral studies of the effects of moderate oligemic hypoxia caused by bilateral clamping of carotid arteries in mice. Impairment of spatial working memory. Pol J Pharmacol 1998, 50, 279-289.
• 11. Krieger R.I.: Handbook of pesticide toxicology. Ed. Academic Press, New York, 2001, pp. 953-965.
• 12. Kunimatsu T., Kamita Y., Isobe N., Kawasaki H.: Immunotoxicological insignificance of fenitrothion in mice and rats. Fundam Appl Toxicol 1996, 33, 246-253.
• 13. Lichtfield J.T., Wilcoxon F.A.: Simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949, 96, 99-113.
• 14. Morris R.G.M.: Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984, 11, 47-60.
• 15. Muir W., Skarda R.T., Milne D.W.: Evaluation of xylazine and ketamine hydrochloride anesthesia in horses. Am J Vet Res 1977, 38, 195-201.
• 16. Rejdak R., Rejdak K., Sieklucka-Dziuba M.: Effect of MK-801 on pilocarpine-evoked seizures in mice exposed to transient incomplete brain ischemia. Pol J Pharmacol 2000, 52, 275-281.
• 17. Salfizadeh S., Pourjafar M., Naghadeh B., Jalali F.S.S.: Caudal extradural analgesia with lidocaine, xylazine, and a combination of lidocaine and xylazine in the Iranian river buffalo. Bull Vet Inst Pulawy 2007, 51, 285-288.
• 18. Sarikaya R., Selvi M., Erkoc F.: Investigation of acute toxicity of fenitrothion on peppered corydoras (Corydoras paleatus) (Jenyns, 1842). Chemisphere 2004, 56, 697-700.
• 19. Sieklucka M., Bortolotto Z., Heim C., Block F., Sontag K.H.: Decreased susceptibility to seizures induced by bicuculline after transient bilateral clamping of the carotid arteries in rats. J Neural Transm Gen Sect 1991, 83, 127- 137.
• 20. Sieklucka M., Heim C., Block F., Sontag K.-H.: Transient reduction of cerebral blood flow leads to long lasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures. J Neural Transm 1992, 88, 87-94.
• 21. Sieklucka M., Löscher W., Heim C., Sontag K.-H.: Influence of short-lasting bilateral clamping of carotid arteries (BCCA) on GABA turnover in rat brain structures. Neurochem Res 1994, 19, 367-372.
• 22. Stephenson J.C., Blevins D.I., Christie G.J.: Safety of Rompun/Ketaset combination in dogs. Vet Med Small Anim Clin 1978, 73, 303-305.
• 23. Wolff M., Benhassine N., Costet P., Hen R., Segu L., Buhot M.C.: Delay-dependent working memory impairment in young-adult and aged 5-HT1BKO mice as assessed in a radial-arm water maze. Learn Memory 2003, 10, 401-409.