Advances with phospholipid signalling as a target for anticancer drug development

• Autorzy: Powis G. , Berggren M. , Gallegos A. , Frew T. , Hill S. , Kozikowski A. , Bonjouklian R. , Zalkow L. , Abraham R. , Ashendel C. , Schultz R. , Merriman R.
• Języki publikacji: EN

Abstrakty

EN

The phosphatidylinositol-3-kinases (PtdIns-3-kinase) are a family of enzymes involved in the control of cell replication. One member of the family, the mammalian pll0/p85 PtdIns-3-kinase, is a potential target for anticancer drug development because of its role as a component of growth factor and oncogene activated signalling pathways. There are a number of inhibitors of this PtdIns-3-kinase, the most potent being wortmannin (IC50 4 nM). Wortmannin inhibits cancer cell growth and has shown activity against mouse and human tumor xenografts in mice. Other inhibitors of the PtdIns-3-kinase are halogenated quinones which also inhibit cancer cell growth and have some in vivo antitumor activity. Some D-3-deoxy-3-substituted mt/o-inositol analogues and their corresponding Ptdlns analogues have been synthesized. They may act as mi/o-inositol antimetabolites in the PtdIns-3-kinase pathway and they can inhibit cancer cell growth.

Słowa kluczowe

EN

cancer cell; anticancer drug; mice; cancer drug; growth; phospholipid signalling; mouse; glycosylphosphatidylinositol anchor; antitumour activity; tumour; phospholipase; human tumour; phosphatidylinositol 3-kinase

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 4
• Opis fizyczny: p.395-403,fig.

Twórcy

autor

Powis G.

• University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724 U.S.A.

autor

Berggren M.

autor

Gallegos A.

autor

Frew T.

autor

Hill S.

autor

Kozikowski A.

autor

Bonjouklian R.

autor

Zalkow L.

autor

Abraham R.

autor

Ashendel C.

autor

Schultz R.

autor

Merriman R.

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