Kisspeptyna - neurohormon o kluczowej roli w rozrodzie

• Autorzy: Klocek-Gorka B , Zieba D.A.

Warianty tytułu

EN

Kisspeptin - a neurohormone of the crucial role in reproduction

• Języki publikacji: PL

Abstrakty

EN

Kisspeptin is a newly-discovered neurohormone, which is secreted from the hypothalamus. Initially it was thought that kisspeptin takes part in metastasis suppression. However, nowadays it is known that this hormone plays an essential role in the modulation of the hypothalamus-pituitary-gonadal axis. It has been demonstrated that mutation in the gene encoding kisspeptin’s receptor causes hypogonadotrophic hypogonadism and infertility in animals and humans. It is well established that kisspeptin may directly stimulate hypothalamic neurons. In addition, this neurohormone directly affects the pituitary and gonads. In the current review the authors sum up all information about different ways of direct and indirect effects of kisspeptin on reproductive processes and also present a novel insight into the mechanism responsible for the feedback loop of estrogen and androgen in mammals.

Słowa kluczowe

PL

rozrod zwierzat; fizjologia rozrodu; neurohormony; kisspeptyna; dzialanie

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2008
• Tom: 64
• Numer: 09
• Opis fizyczny: s.1087-1090,rys.,bibliogr.

Twórcy

autor

Klocek-Gorka B

• Akademia Rolnicza w Krakowie, Al.Mickiewicza 24/28, 31-120 Krak�w

autor

Zieba D.A.

Bibliografia

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• 2. Castellano J. M., Gaytan M., Roa J., Vigo E., Navarro V. M., Bellido C., Dieguez C., Aguilar E., Sanchez-Criado J. E., Pellicer A., Pinilla L., Gaytan F., Tena-Sempere M.: Expression of Kiss-1 in rat ovary: putative local regulator of ovulation? Endocrinology 147, 4852-4862.
• 3. Dhillo W. S., Chaudhri O. B., Patterson M., Thompson E. L., Murphy K. G., Badman M. K., McGowaan B. M., Amber V., Patel S., Ghatei M. A., Bloom S. R.: Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males. J. Clin. Endocrinol. Metab. 2005, 90, 6609-6615.
• 4. Dhillo W. S., Murphy K. G., Bloom S. R.: The neuroendocrine physiology of kisspeptin in the human. Rev. Endocr. Metab. Disord. 2007, 8, 41-46.
• 5. Dungan H. M., Clifton D. K., Steiner R. A.: Minireview: kisspeptpin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 2006, 147, 1154-1158.
• 6. Fernandez-Fernandez R., Martini A. C., Navarro V. M., Castellano J. M., Dieguez C., Aguilar E., Pinilla L., Tena-Sempere M.: Novel signals for the integration of energy balance and reproduction. Mol. Cell. Endocrinol. 2006, 254-255, 127-132.
• 7. Gottsch M. L., Cunningham M. J., Smith J. T., Popa S. M., Acohido B. V., Crowley W. F., Seminara S., Clifton D. K., Steiner R. A.: A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 2004, 145, 4073-4077.
• 8. Greives T. J., Mason A. O., Scotti M.-A. L., Levine J., Ketterson E. D., Kriegsfeld J., Demas G. E.: Environmental control of kisspeptin: implications for seasonal reproduction. Endocrinology 2007, 148, 1158-1166.
• 9. Irwing M. S., Fraley G. S., Smith J. T., Acohido B. V., Popa S. M., Cunningham M. J., Graier W., Clifton D. K., Steiner R. A.: Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 2004, 80, 264-272.
• 10. Kuohung W., Kaiser U. B.: GPR54 and KiSS-1: role in the regulation of puberty and reproduction. Rev. Endocr. Metab. Disord. 2006, 7, 257-263.
• 11. Lapatto R., Pallais J. C., Zhang D., Chan Y.-M., Mahan A., Cerrato F., Le W. W., Hoffman G. E., Seminara S. B.: Kiss1 -/- mice exhibit more variable hypogonadism than Gpr54 -/- mice. Endocrinology 2007, 148, 4927-4936.
• 12. Messager S., Chatzidaki E. E., Ma D., Handrick A. G., Zahn D., Dixon J., Thresher R. R., Malinge I., Lomet D., Carlton M. B. L., Colledge W. H., Caraty A., Aparicio S. A. J. R.: Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc. Natl Acad. Sci. USA 2005, 102, 1761-1766.
• 13. Plant T. M.: The role of KiSS-1 in the regulation of puberty in higher primates. Eur. J. Endocrinol. 2006, 155, 11-16.
• 14. Pompolo S., Pereira A., Estrada K. M., Clarke I. J.: Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain. Endocrinology 2006, 147, 804-810.
• 15. Revel F. G., Saboureau M., Masson-Pevet M., Pevet P., Mikkelsen J. D., Simonneaux V.: Kiss-1: a likely canidate for the photoperiodic control of reproduction in seasonal breeders. Chronobiol. Int. 2006, 13, 277-287.
• 16. Revel F. G., Saboureau M., Masson-Pevet M., Pevet P., Mikkelsen J. D., Simonneaux V.: Kisspeptin mediates the photoperiodic control of reproduction in hamster. Curr. Biol. 2006, 16, 1730-1735.
• 17. Seminara S. B.: We all remember our first kiss: kisspeptin and the male gonadal axis. J. Clin. Endocrinol. Metab. 2005, 90, 6738-6740.
• 18. Smith J. T., Dungan H. M., Stoll E. A., Gottsch M. L., Braun R. E., Eacker S. M., Clifton D. K., Steiner R. A.: Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 2005, 146, 2976-2984.
• 19. Sztuka A., Zdrojewicz Z.: Kisspeptin - Hormon of puberty? Adv. Clin. Exp. Med. 2006, 15, 949-952.
• 20. Thompson E. L., Patterson M., Murphy K. G., Smith K. L., Dhillo W. S., Todd J. F., Ghatei M. A., Bloom S. R.: Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J. Neuroendocrinol. 2004, 16, 850-858.