Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor

• Autorzy: Politowska E. , Kazmierkiewicz R. , Wiegand V. , Fahrenholz F. , Ciarkowski J.
• Języki publikacji: EN

Abstrakty

EN

Cholesterol, an integral component of membranes in Eucaryota, is a modifier of mem­brane properties. In vivo studies have demonstrated that cholesterol can also modulate ac­tivities of some G protein-coupled receptors (GPCRs), which are integral membrane pro­teins. This can result either from an effect of cholesterol on the membrane fluidity or from specific interactions of the membrane cholesterol with the receptor, as recently demon­strated for the cholecystokinin type β (CCKRβ ) or the oxytocin receptor (OTR). Using mo­lecular modelling, we studied conformational preferences of cholesterol and several of its analogues. Subsequently, we simulated the distributions of their preferred conformations around the surface of OTR, CCKR β and a chimeric oxytocin/cholecystokinin receptor. Consequently, we suggest residues on the surface of OTR which are potentially significant in the OTR/cholesterol interaction.

Słowa kluczowe

EN

molecular modelling; membrane property; membrane; sterol; cholecystokinin receprot type beta; Eukaryota; oxytocin receptor; cholesterol

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 1
• Opis fizyczny: p.83-93,fig.

Twórcy

autor

Politowska E.

• University of Gdansk, J.Sobieskiego 18, 80-952 Gdansk, Poland

autor

Kazmierkiewicz R.

autor

Wiegand V.

autor

Fahrenholz F.

autor

Ciarkowski J.

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