Inaktywowana szczepionka przeciwko grzybicy skornej kotow wywolywanej przez Microsporum canis

• Autorzy: Wawrzkiewicz K , Sadzikowski Z. , Ziolkowska G. , Wawrzkiewicz J.
• Języki publikacji: PL

Abstrakty

EN

The purpose of the work was to determine the protective properties of a vaccine, called Felisvac Me, developed according to the authors’ own technology. Examinations were carried out on 33 domestic, shorthaired cats 1-6 months of age. The degree of specific immunity was evaluated by a challenge trial, contact infection (simulation of natural contagion), delayed type of hypersensitivity test and the migration inhibition test of leukocytes. It was found that the vaccine without an adjuvant in a dose of 2 ml did not fully protect one-month old cats from being infected with a virulent strain of M. canis. Cats, which were given a higher dose of the vaccine (3 ml per animal) adsorbed on aluminium hydroxide, turned out to be immune to both methods of infection by challenge trials. The vaccine elicited a delayed type of hypersensitivity that persisted on almost a similar level (0.8--1.1 mm) throughout the observation period, i.e. 5 months. Positive values (25.2-32.4%) of the leukocyte migration inhibition test - the consecutive determinant of cellular type of immunity, were found between 22 and 41 days after vaccination. The above vaccine is characterised by a high protective value; it is also safe for both animals and environment. No side effects have been observed.

Słowa kluczowe

PL

Microsporum canis; grzybica skory; koty; skutecznosc; szczepienia ochronne; etiologia; choroby zwierzat; szczepionki inaktywowane; immunoprofilaktyka

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2000
• Tom: 56
• Numer: 04
• Opis fizyczny: s.245-250,rys.,fot.,tab.,bibliogr.

Twórcy

autor

Wawrzkiewicz K

• Akademia Rolnicza, ul. Akademicka 12, 20-033 Lublin

autor

Sadzikowski Z.

autor

Ziolkowska G.

autor

Wawrzkiewicz J.

Bibliografia

• 1. Adamski Z, Bowszyc J., Pawłowicz A., i wsp.: Doustna postać Lamisolu (ter- binafme) Sandoz w leczeniu grzybicy stóp. Polskie badania wieloośrodkowe. Mikol. Lek. 1994, 1, 19-22.
• 2. Baundraz-Rosselel F, Mond M., Jaccoud S., FrenkE.: Efficacy of terbinafine treatment of tinea capitis in children varies according to the dermatophytes species. Br. J. Dermatol. 1996, 135, 1011-1012.
• 3. Bredahl L., Fougner J. A., Brattberg A. M., Lund A.: Ringworm in farmed foxes in Norway. Norsk Veterinaertidsskrift 1997, 109, 167-169.
• 4. Brumm F.: Microsporum infection in cats. Praca dokt. Tierarztliche Hochschule, Hannover, 1985, s. 196.
• 5. Carlotti D. N.: Grzybice skóry u psów i kotów. Mat. II Międzynarod. Symp. Dermatolog. 22. 04. 1995. Instytut Weterynarii, Puławy, 1995, 4-9.
• 6. CarriUo-Munoz A. J.. Tur-Tur C.: Comparative study of antifungal activity of seraconazole, terbinafine and bifonazole against clinical isolated of Candida sp., Cryptococcus neoformans and dermatophytes. Chemotherapy (Basel), 1997, 43, 387-392.
• 7. DeBoer D. J.. Moriello K. A.: Investigations of a killed dermatophyte cell-wall vaccine against infection with Microsporum canis in cats. Res. Vet. Sci. 1995, 59, 110-113.
• 8. DeBoer D. J., Moriello K. A:. The immune response to Microsporum canis induced by a fungal cell-wall vaccine. Vet. Dermatol. 1994, 5, 47-55.
• 9. De Vroey C, Desmet P., Li Q. Z., Mukamuragawa P, Raes-Waytach C.: Further studies on the in vitro antifungal activity of amorolfine. Mycoses 1996, 39,41-44.
• 10. Elad D., Segal E.: Immunogenicity in guinea-pigs of a crude ribosomal fraction from Microsporum canis. Vaccine 1994, 12, 134-137.
• 11. Ferreiro L., Chermetta R, Polach B.. Guillot J.; Microsporum canis: on century (1897-1997) of continuous dissemination around the world. XIII Congress ISHAM, Parma, 1997, 188.
• 12. Gordon P. J.. Bond R.: Efficacy of a live attenuated Trichophyton verrucosum vaccine for control of bovine dermatophytosis. Vet. Rec. 1996, 139, 395-396.
• 13. Gregory R. J.; Microbial ribosomal vaccine. Rev. Infect. Dis. 1986, 8, 208- -217.
• 14. Greisen A.: Dermatophytosis - occurence of subclinical dermatophytosis in cats in households where is human dermatophyte infection. Danks-Vetemaer- tidsskrift 1997, 80, 454-457.
• 15. Gudding R., Naess В.: Vaccination of cattle against ringworm caused by Trichophyton verrucosum. Am. J. Vet. Res. 1986, 47, 2415-2417.
• 16. MacKenzie D. W. R., Loeffler W, Mantovani A., Fujikura T.: Guidelines for diagnosis, prevention and control of dermatophytes in man and animal. World Health Organization, Geneva (WHO/CDS/VBH), 1988, s. 55.
• 17. MacKenzie D. W. R.. Loeffler W, Mantovani A., Fujikura T.: Guidelines for the diagnosis, prevention and control of dermatophytoses in man and animal. Words Health Organization 1986; WHO/CDS/VPH 86, 67, 1-83.
• 18. McKenzie D. W. R.: „Hairbrush diagnosis” in detection and eradication ofnon- fluorescent scalp ringworm. Br. Med. J. 1963, 2, 363-365.
• 19. Marchisio V. F, Gallo M. G., ТиШо V., Nepote S., Piscozzi A., Cassinelli C.: Dermatophytes from cases of skin disease in cats and dogs in Turin, Italy. Mycoses 1995, 38, 239-244.
• 20. Nikiforov L. J., Zharkov J. J., Slugin V. S., Chuchina T. V., Noginov V. K., Bordasova О. V, Mukhemetshin R. V.: Control measures against Microsporum. Vet. Bull. 1990, 60, 990.
• 21. Niwano Y, KuzuharaN., KodamaH., Yoshida M., Miyazaki T, YamaguchiH:. In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob. Agents Chemother., 1998, 42, 967-970.
• 22. Otcenacek M.. Stros K.. Komárek. J., Tomsikova A., Raškova H., Hamacek F.: Vaccination of cattle against trichophytosis in the prevention and control of dermatophytic zoonoses. Vet. Med. (Praha) 1981, 26, 193-202.
• 23 .Pier A. C, Smith J. M. B., Alexiou D. H., Ellis D. H., Lund A., Pritchard R. C.: Animal ringworm - its aetiology, public health significance and control. J. Med. Vet. Mycol. 1994, 32 (suppl. 1), 133-150.
• 24. Pier A. C., Zancanella P. J:. Immunization of horses against dematophytosis caused by Trichophyton equinum. Equine Pract., 1993, 15, 23-27.
• 25. Rybnikar A., Chumela J.. Vrzal V, Lysal J., Petras J.: Vaccination of horses against trichophytosis. Acta Vet. (Brno) 1991, 60, 165-169.
• 26. Sarkisov А. K. H. : Specific prophylaxis of trichophytosis in cattle. Vet. Bull. 1980, 50, 194.
• 21. Sarkisov А. K. H., Koromyslov G.: Proposal for the prevention and control of dermatophytoses common to man and animals. World Health Organization 1983, WHO/ZOON/83, 162, 1-7.
• 28. Siesenop U., Bohm K. H., Brandebusemeyer E., Conrad P.: Virulence, safety and efficacy of „Bioveta live vaccine against ringworm in cattle”. Prakt. Tierarzt, 1994, 75, 605-612.
• 29.Siesenop U., Busse M, Bohm K. H.: The importance of dermatophytosis in dogs and cats - a review of 11 years of routine mycological diagnostic work. Kleintierpraxis 1996, 41, 483-491.
• 30 .Smith J. M. B., Aho R., Mattisson R.. Pier A. C.: Progress in veterinary mycology. J. Med. Vet. Mycol. 1992, 30 (suppl. 1), 307-316.
• 31. Smith J. M. B.. Griffin J. F. T.: Strategies for the development of a vaccine against ringworm. J. Med. Vet. Mycol. 1995, 33, 87-91.
• 32. Sparkes A.FI., Gruffyddjones T. J., Shaw S. E., Wright A. J., Stokes C. R.: Epidemiologic and diagnostic features of canine and feline dermatophytosis in the United Kingdom from 1956-1991. Vet. Rec. 1993, 133, 57-61.
• 33. Stantic-Pavlinic M., Grile E., Marinic-Fiser N.: An epidemiological survey of Microsporum canis - related infection in Ljubljana. Alpe Adria Microbiol. J. 1997, 6, 165-168.
• 34. Tausch J.. Brautigam M, Weidinger G., Jones T. C:. Evaluation of 6 weeks treatment of terbinafine in tinea unguinum in a double-blind trial comparing 6 and 12 weeks therapy. Br. J. Dermatol., 1997, 136, 737-742.
• 35 .Tornquist M, Bendixen P. H., Pehrson B.: Vaccination against ringworm of calves in specialized beef production. Acta Vet. Scand. 1985, 26, 21-29.
• 36. Wawrzkiewicz J., Wawrzkiewicz K., Sadzikowski Z.: Monowalentna i skojarzona szczepionka inaktywowana w profilaktyce trychofitozy lisów hodowlanych. Medycyna Vet. 1991, 47, 317-320.
• 37. Wawrzkiewicz K., Wawrzkiewicz J.: An inactivated vaccine against ringworm. Comp. Immunol. Microbiol. 1992, 15, 31-40.
• 38. Wawrzkiewicz K., Wawrzkiewicz J.: Early immunization of calves with inactivated vaccine against trichophytosis. Pol. Arch. Wet. 1988, 28, 5-16.
• 39. Wawrzkiewicz K., Wawrzkiewicz J., Sadzikowski Z.: Doświadczalna infekcja M. canis u lisów hodowlanych - leczenie i swoista immunoprofilaktyka. Medycyna Wet., 1993, 49, 543-547.
• 40. Wawrzkiewicz K., Ziółkowska G:. Specific immunoprophylaxis in Microsporum canis infection in guinea-pigs. J. Mycol. Med. 1996, 6, 56-62.
• 41. Wawrzkiewicz K., Ziółkowska G., Sadzikowski Z.: An assessement of the immune response of cats experimentally infected with Microsporum canis - w druku.
• 42. WHO/ISHAM Liaison Committee. Proceedings ISHAM Consultation of Prevention and Control of Dermatophytosis with special reference to immunity and immunization. National Veterinary Institute, Oslo, Norway, 1987.
• 43. Wołoszyn S., Andrychiewicz J., Kostro K., Winiarczyk S., Grądzki Z.: Skuteczność szczepionek w zwalczaniu grzybic skórnych królików. Medycyna Wet. 1996, 52, 518-521.
• 44. Ziółkowska G., Wawrzkiewicz K.: The immunological evaluation of the vaccines against the Microsporum canis infection. Annales UMCS (Lublin) section DD, 1998, 53, 17-27.