New approaches to the mapping of chromosomal domains

• Autorzy: Filipski J. , Svetlova E. , Avril-Fournout N. , Deschavanne P. , Bellis M.
• Języki publikacji: EN

Abstrakty

EN

Although it is generally accepted that the chromosome is divided into elementary subunits/ the structural and functional domains/ the organisation of these structures at the molecuJar level is not well understood. In particular, the domain boundaries are not easily identifiable. Several possible candidates such as MARs/SARs, insulators, LCRs, palindromic sequences, or easily melting sequences have been found in the regions having properties one would except for boundaries. None of these elements, however, has been found in all of the constructs functioning as boundaries in tests in vivo. Recent work suggests that the common denominator might be the presence of GC-rich oligonucleotide streches and the formation of the chromatin hypersensitive sites. A model is discussed in which "unusual" structures, in particular the four-stranded DNA sequence elements containing unpaired bases, play the role of domain boundaries.

Słowa kluczowe

EN

hypersensitive site; locus control region; scaffold attached region; chromosome; matrix associated region; chromosomal domain; melting sequence; DNA

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 2
• Opis fizyczny: p.289-292,fig.

Twórcy

autor

Filipski J.

• Institute J.Monod, 2 place Jusieu tour 43, 75251, Paris, France

autor

Svetlova E.

autor

Avril-Fournout N.

autor

Deschavanne P.

autor

Bellis M.

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