Nonhistone chromosomal proteins [NHCP] in adenocarcinoma of human endometrium

• Autorzy: Miturski R.
• Języki publikacji: EN

Abstrakty

EN

Concentration and electrophoretic pattern of nonhistone chromosomal proteins (NHCP) in cancer and normal endometrium were examined. In normal tissues the NHCP/DNA ratio ranged from 0.6 to 0.8 whereas in malignant tissues from 1.2 to 1.7. Mean nuclear concentration of NHCP was 14.16 pg/cell nucleus of normal endometrium and 33.35 pg/cell nucleus of cancer tissue. The two tissues differed in the electrophoretic pattern. Heavy fractions (>60 kDa — 36%) predominated in normal tissue whereas light fractions (< 30 kDa — 48%) in malignant tissue samples. The percentage of intermediate fractions (30-60 kDa) was similar. Neoplastic endometrium shows, irrespective of the patient's age, a high NHCP content. It seems that NHCP, especially the fraction extracted with 0.35 M NaCl, because of its tissue and cell specificity are involved in neoplasm formation.

Słowa kluczowe

EN

human endometrium; nonhistone chromosomal protein; adenocarcinoma; woman; neoplastic endometrium; cancer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 2
• Opis fizyczny: p.191-195,fig.

Twórcy

autor

Miturski R.

• Medical Academy of Lublin, Jaczewskiego 8, 20-950 Lublin, Poland

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