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2008 | 64 | 02 |

Tytuł artykułu

Stezenie insulinopodobnych czynnikow wzrostu IGF-I i IGF-II w surowicy zrebnych klaczy w okresie okoloimplantacyjnym

Warianty tytułu

EN
Serum concentration of IGF-I and IGF-II in pregnant mares during a perimplant period

Języki publikacji

PL

Abstrakty

EN
In the reproduction of animals and humans, insulin-like factors (IGF-I , IGF-II) play a significant role. Among others, they stimulate growth of the ovarian follicle, embryo development, egg implantation and they inhibit cell apoptosis. In horses the implantation process and placenta development is partly regulated by IGF-I and IGF-II. Research was conducted on 18 mares during early pregnancy. The study has revealed the existence of some differences in the level of IGF-I and IGF-II. A significant increase of IGF-I in comparison to the preovulation period (311 ng/ml) was noted 12 h after ovulation (356 ng/ml), 72 h (328 ng/ml), 7 days (340 ng/ml) and at 35 (344 ng/ml) and at 55 (360 ng/ml) days of gestation. The concentration of IGF-II also increased but only at the 6th day after ovulation. The concentration of IGF-II before ovulation was 4.8 ng/ml and up until the 6 days after ovulation it ranged from 8.2 to 9.6 ng/ml. The differences in the levels of IGF-I and IGF-II before and after ovulation and during the pregnancy could result from the activation of an embryo genome and from the preparation of endometrium for implantation.

Wydawca

-

Rocznik

Tom

64

Numer

02

Opis fizyczny

s.237-239,rys.,bibliogr.

Twórcy

autor
  • Akademia Rolnicza w Lublinie, ul.Gleboka 30, 20-612 Lublin
autor
autor

Bibliografia

  • 1. Carneiro G., Lorenzo P., Pimentel C., Pegoraro L., Bertolini M., Ball B., Anderson G., Liu I.: Influence of insulin-like growth factor-I and its interaction with gonadotropins, estradiol, and fetal calf serum in vitro maturation and parthenogenic development in equine oocytes. Biol. Reprod. 2001, 56, 889-905.
  • 2. Champion Z. J., Breier B. H., Ewen W. E., Tobin T. T., Casey P. J.: Blood plasma concentration of insulin-like growth factor-I (IGF-I) in resting standardbred horses. Vet. J. 2002, 163, 45-50.
  • 3. Davidson T. R., Chamberlain C. S., Bridges S., Spicer L. J.: Effect of follicle size on in vitro production of steroids and insulin-like growth factor (IGF-I), IGF-II, and the IGF-binding proteins by equine ovarian granulosa cells. Biol. Reprod. 2002, 66, 1640-1648.
  • 4. Deichsel K., Aurich J., Parvizi N., Bruckmaier R. M., Aurich C.: LH and IGF-I release during oestrus and early luteal phase in lactating and non-lactating horse mares. Anim. Reprod. Sci. 2006, 91, 97-106.
  • 5. Fabian D., Il'kova G., Rehák P., Czikková S., Baran V., Koppel J.: Inhibitory effect of IGF-I on induced apoptosis in mous preimplantation embryos cultured in vitro. Theriogenology 2004, 61, 745-755.
  • 6. Fabian D., Koppel J., Maddox-Hyttel P.: Apoptosis processes during mammalian preimplantation development. Theriogenology 2005, 64, 221-231.
  • 7. Herrler A., Krusche C. A., Beier H. M.: Insulin and insulin-like growth factor-I promote rabbit blastocyst development and prevent apoptosis. Biol. Reprod. 1998, 59, 1302-1310.
  • 8. Hess-Dudan F., Vacher P. Y., Bruckmaier R. M., Weishaupt M. A., Burger D., Blum J. W.: Immunoreactive insulin-like growth factor I and insulin in blood plasma and milk of mares and in blood plasma of foals. Equine Vet. J. 1994, 26, 134-139.
  • 9. Hul K. L., Harvey S.: Growth hormone: role in female reproduction. J. Endocrinol. 2001, 168, 1-23.
  • 10. Kooijman R.: Regulation of apoptosis by insulin-like growth factor (IGF)-I. Cytokine 2006, 17, 305-323.
  • 11. Kurpisz M.: Molekularne podstawy rozrodczości człowieka i innych ssaków. Termedia Wydawnictwa Medyczne, Poznań 2002, s. 152.
  • 12. Lennard S. N., Stewart F., Allen W. R.: Insulin-like growth factor II gene expression in the fetus and placenta of the horse during the first half of gestation. J. Reprod. Fertil. 1995, 103, 169-179.
  • 13. Letcher R., Simmen R. C., Bazer F. W., Simmen F. A.: Insulin-like growth factor-I expression during early conceptus development in the pig. Biol. Reprod. 1989, 41, 1143-1151.
  • 14. Malinowski K., Christensen R. A., Hafs H. D., Scanes C. G.: Age and breed differencens in thyriod hormones, insulin-like growth factor (IGF-I) and IGF binding proteins in female horses. J. Anim. Sci. 1996, 74, 1936-1942.
  • 15. Ozawa A., Inokuma H., Johke T.: The relationship between plasma insulin-like growth factor-I (IGF-I) level and body weight in the horse. J. Vet. Med. Sci. 1995, 57, 1105-1107.
  • 16. Popot M. A., Bobin S., Bonnaire Y., Delahaut P. H., Closset J.: IGF-I plasma concentrations in non-treated horses and horses administered with methionyl equine somatotropin. Res. Vet. Sci. 2001, 71, 167-173.
  • 17. Schäfer-Somi: Cytokines during early pregnacy of mammals: a review. Anim. Reprod. Sci. 2003, 75, 73-94.
  • 18. Walters K. W., Roser J. F., Anderson G. B.: Maternal-conceptus signalling during early pregnancy in mares: oestrogen and insulin-like growth factor I. Reprod. 2001, 121, 331-338.
  • 19. Yimaz A., Davis M. E., Simmen R. C. M.: Analysis of female reproductive traits in Angus beef divergently selected for blood serum insulin-like growth factor I concentration. Theriogenology 2006, 65, 1180-1190.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-84016ec2-34e8-4d93-bb7e-c5c80b8a7a46
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