EN
In the chinchilla farm (1000 animals) many cases of sickness and mortality (8%) were noted. Twenty died chinchilla were examined. The symptoms of diarrhea, dehydration and pyometritis were stated. Pseudotuberculosis hepatitis, enteritis catarrhalis, lymphadenitis mesenterica, splenitis haemorrhagica and interstitial pneumonia were found during autopsy. A profuse growth of enterotoxigenic strain of Yersinia pseudotuberculosis (RPLA test) was obtained from the internal organs of the chinchillas. Clinical signs, gross lesions and bacteriological examinations suggest a septicaemic nature of the disease. All chinchilla from the farm were treated with an immunomodulator (Propionibacterium acnes, t.I) and then vaccinated with a formalin inactivated culture of Y. pseudotuberculosis. In conclusion the efficacy of immunoprophylaxis of yersiniosis by means of an immunomodulator (P. acnes) and Y. pseudotuberculosis vaccine was clinically demonstrated.