Prenyl sulfates as alkylating reagents for mercapto amino acids

• Autorzy: Maltsev S. , Sizova O. , Utkina N. , Shibaev V. , Chojnacki T. , Jankowski W. , Swiezewska E.
• Języki publikacji: EN

Abstrakty

EN

A new methodology for prenylation of thiol compounds has been developed. The approach is based on the use of prenyl sulfates as new reagents for S-prenylation of benzenethiol and cysteamine in aqueous systems. The C10-prenols geraniol and nerol that differ in the configuration (E or Z, correspondingly) of the α-isoprene unit were efficiently O-sulfated in the presence of a pyridine-SO3,complex. The obtained geranyl and neryl sulfates were tested as alkylating agents. These compounds were chosen to reveal the influence of the α-isoprene unit configuration on their alkylation (prenylation) ability. S-Geranyl cysteine was prepared to demonstrate the applicability of this method for prenylation of peptides containing mercapto amino acids.

Słowa kluczowe

PL

prenyl sulphate; amino acid; lipidated amino acid; geraniol; nerol; cysteamine; cysteine; thiol compound; prenylation; new methodology

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2008
• Tom: 55
• Numer: 4
• Opis fizyczny: p.807-813,fig.,ref.

Twórcy

autor

Maltsev S.

• Russian Academy of Sciences, Leninsky prospect 47, Moscow, 119991, Russian Federation

autor

Sizova O.

autor

Utkina N.

autor

Shibaev V.

autor

Chojnacki T.

autor

Jankowski W.

autor

Swiezewska E.

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