PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Czasopismo

2007 | 53 | 3 |

Tytuł artykułu

Antioxidant activity of grapefruit extract from Citrus paradisi seeds and pulp

Warianty tytułu

PL
Aktywnosc antyoksydacyjna ekstraktu z nasion i pulpy owocu Citrus paradisi

Języki publikacji

EN

Abstrakty

EN
Epidemiological studies have suggested associations between polyphenol-rich food con­sumption and the prevention of diseases. Currently, there is much interest in the health- fulness of citrus fruits because their intake appears to be associated with reduced risk of certain chronic diseases. In the paper a review of recent studies on antioxidant activity and physiological effect of grapefruit flavonoides has been conducted. Antioxidant activity of grapefruit extract has been studied in vitro and in vivo. It has been found that grapefruit compounds demonstrate good antioxidant potential, inhibit superoxide formation, show strong scavenging activity and anti-apoptopic activity. Results showed that hesperidin and naringin as well as their aglycones hesperedin and naringenin are mainly responsible for antioxidative activity of grapefruit extract and grapefruit juice. Citrus flavonoids became subjects of great concern with discovery of these compounds effects on capillary function. Research has also shown that citrus flavonoids and their metabolites are potent antioxi­dants. Thus, they are able to suppress many cases of cancer and inflammation involving reactive oxygen species. Recently published results concerning grapefruit potential in hu­mans show that diet supplemented with red grapefruit positively influences serum lipid levels of all fractions, especially serum triglycerides as well as serum antioxidant activity.
PL
Badania epidemiologiczne wskazują na występowanie związków między spożyciem żywności bogatej w polifenole a prewencją schorzeń. Szczególnym zainteresowaniem cieszą się owoce cytrusowe, których spożycie wiązane jest z obniżaniem ryzyka wielu chorób. W artykule dokonano przeglądu prac na temat aktywności antyoksydacyjnej i fiz­jologicznego oddziaływania flawonoidów występujących w owocach grapefruita. Aktywność antyoksydacyjna ekstraktu grapefruita badana była zarówno in vitro, jak in vivo. Dowiedziono, że ekstrakt wykazuje wysoki potencjał antyoksydacyjny, wychwytuje wolne rodniki, a także hamuje ich powstawanie, ma także hamujący wpływ na rozwój komórek rakowych, a jednym z mechanizmów tego działania jest apoptoza. Bioflawonoidy grejpfru­ta wykazują również działanie przeciwzapalne. Najnowsze badania wskazują również na korzystny wpływ spożycia owoców czerwonego grapefruita na poziom lipidów we krwi, szczególnie trójglicerydów. Wyniki badań wskazują, że za właściwości antyoksydacyjne ekstraktu i soku z grejpfruta odpowiadają flawanony - naringenina oraz jej glikozyd naringina, a także hesperydyna.

Wydawca

-

Czasopismo

Rocznik

Tom

53

Numer

3

Opis fizyczny

p.380-384,ref.

Twórcy

autor
  • Warsaw Agricultural University, Nowoursynowska 159C, 02-787 Warsaw, Poland

Bibliografia

  • 1. Peterson J, Beecher G, Bhagwat S, DwyerJ, Gebhardt S, Haytowitz D, HoldenJ. Flavanones in grapefruit, lemons, and limes: A compilation and review of the data from the analytical literature. J Food Compost Anal 2006; 19:74-80.
  • 2. Vanamala J, Reddivari L, Yoo KS, Pike L, Patil B. Variation in the content of bioactive flavonoids in different brands of orange and grapefruit juices. J Food Compost Anal 2006; 19: 157-66.
  • 3. Erlund I, Meririnne E, Alfthan G, Aro A. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr 2001; 131:235-41.
  • 4. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr 2000; 130, 8S:2073S-86S.
  • 5. Hollman PC, Bijsman MN, van Gameren Y, Cnossen EP, de Vries JH, Katan MB. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radie Res 1999; 31:569-73.
  • 6. Jay M, Viricel M, Gönnet J. C-Glycosylflavonoids. In: Flavonoides. Chemistry, biochemistry and applications. Ed. Andersen 0. & Markham K„ CRC Taylor & Francis Group, London 2006.
  • 7. Proteggente A, Rice-Evans C, Wiseman S, Put F. The relationship between the phenolic composition and the antioxidant activity of fruits and vegetables. In: Flavonoids in health and disease. Rice-Evans C & Packer L„ Marcel Dekker, Inc., Nw York 2003.
  • 8. Nijveldt R, Nood E, Hoorn D, Boelens P, Norren K, Leeuwen P. Flavonoids: a review of probable mechanisms of action and potential applications. AmJ Clin Nutr 2001; 74, 4:418-25.
  • 9. Tirllini B. Grapefruit: the last decade acquisitions. Fitoterapia 2000; 71:29-37.
  • 10. Wilcox LJ, Borradaile NM, Huff. MW. Antiatherogenic properties of naringenin, a citrus flavonoid. Cardiovasc. Drug Rev 1999; 17:160-78.
  • 11. Giamperi L, Fraternale D, Bucchini A, Ricci D. Antioxidant activity of Citrus paradisi seeds glyceric extract. Fitoterapia 2004; 75: 221-4.
  • 12. Yu J, Wang L, Walzern R, Miller E, Pike L, Patil B. Antioxidant activity of citrus limonoids, flavonoids and coumarins. J Agrie Food Chem 2005; 53(6):2009 -14.
  • 13. Alvarez-González I, Madrigal-Bujaidar E, Martino-Roaro L, Espinosa-Aguirre J. Antigenotoxic and antioxidant effect of grapefruit juice in mice treated with daunorubicin. Toxicol Lett 2004; 152:203-11.
  • 14. Kanno S-l, Shouji A, Asou K, Ishikawa M. Effects of Naringin on Hydrogen Peroxide-Induced Cytotoxicity and Apoptosis in P388 Cells. J Pharmacol Sei 2003; 92: 166-70.
  • 15. Robards K, Prenzler P, Tucker G, Swatsitang P, Glover W. Phenolic compounds and their role in oxidative processes in fruits. Food Chem 1999; 66:401-36.
  • 16. Gorinstein S, Caspi A, Libman I, Katrich E, Lerner HT, Trakhtenberg S. Fresh Israeli Jaffa sweetie juice consumption improves lipid metabolism and increases antioxidant capacity in hypercholesterolemic patients suffering from coronary artery disease: studies in vitro and in humans and positive changes in albumin and fibrinogen fractions. J Agrie Food Chem 2004a; 11, 52 (16):5215-22.
  • 17. Gorinstein S, Leontowicz H, Leontowicz M, Krzemiński R, Gralak M, Martin-Belloso O, Delgado- Licon E, Haruenkit R, Katrich E, Park YS, Jung ST, Trakhtenberg S. Fresh Israeli Jaffa blond (Shamouti) orange and Israeli Jaffa red Star Ruby (Sunrise) grapefruit juices affect plasma lipid metabolism and antioxidant capacity in rats fed added cholesterol. J Agrie Food Chem 2004b; 28, 52(15):4853-9.
  • 18. Gorinstein S, Caspi A, Libman I, Lerner HT, Huang D, Leontowicz H, Leontowicz M, Tashma Z, Katrich E, Feng S, Trakhtenberg S. Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans. J Agrie Food Chem 2006; 8, 54(5): 1887-92.
  • 19. Dembiński A, Warzecha Z, Konturek S, Ceranowicz P, Dembiński M, Pawlik W, Kusnierz-Cabala B, Naskalski J. Extract of Grapefruit-Seed Reduces Acute Pancreatitis Induced by Ischemia/Reperfusion in Rats; Possible Implication ofTissue Antioxidants.J Physiol Pharmacol 2004; 55 (4):811-21.
  • 20. Brzozowski T, Konturek P, Drozdowicz D, Konturek S, Zayachivska O, Pajdo R, Kwiecień S, Pawlik W, Hahn E. Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways. WorldJ Gastroenterol 2005; 11(41):6450-8.
  • 21. KyleJ, Duthie G. Flavonoids in Food. In: Flavonoides. Chemistry, Biochemistry and applications. Ed. Andersen 0. 8¡ Markham K„ CRC Taylor & Francis Group, London 2006.
  • 22. Juskiewicz J, Zdunczyk Z, Wróblewska M, Oszmianski J, Hernandez T. The response of rats to feeding with diets containing grapefruit flavonoid extract. Food Res Intern 2002; 35:201-5.
  • 23. Jagetia G, Venkatesha V, Reddy T. Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. Mutagenesis 2003; 18, 4:337-43.
  • 24. Marchand L, Murphy S, Hankin J, Wilkens L, Kolonel L. Intake of favonoids and lung cancer. J Natl Cancer Inst 2000; 92, 2, 19:154-60.
  • 25. Vanamalaj, Leonardi T, Patil B, Taddeo S, Murphy M, Pike L, Chapkin R, LuptonJ, Turner N. Suppression of colon carcinogenesis by bioactive compounds in grapefruit. Carcinogenesis 2006a; 27 (6):1257-65.
  • 26. Benavente-Garcia O., Castillo J, Del Río JA. Uses and properties of citrus flavonoids. J Agrie Food Chem 1997; 45:4505-15.
  • 27. Lee CT, Jeong Y, Choi B, Hyun G, Oh E, KimJ, KimJ, Han S, Bok SH. Anti-atherogenic effects of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits. Biochem Biophys Res Commun 2001; 284:681-8.
  • 28. Jung U, Lee M, Park Y, Kang M, Choi M. Effect of citrus flavonoids on lipid metabolism and glucose- regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol 2006; 38: 1134-45.
  • 29. Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, Hakulinen T, Aromaa A. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002; 76, 3:560-8.
  • 30. Dahan A. Altman H. Food-drug interaction: grapefruit juice augments drug bioavailability-mechanism, extent and relevance. EurJ Clin Nutr 2004; 58(l):l-9.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-823dbe30-816b-44a9-b91d-1c59e9c9a2d6
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.