Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin - new carriers of alkylating elements

• Autorzy: Bartulewicz D. , Markowska A. , Wolczynski S. , Dabrowska M. , Rozanski A.
• Języki publikacji: EN

Abstrakty

EN

A series of netropsin and distamycin analogues was synthesised and investigated by molecular modelling. The lowest-energy conformations of four carbocyclic lexitropsins, potential carriers of alkylating elements, were obtained using the HyperChem 4.0 program, and compared with the DNA-lexitropsin crystal structures from the Brookhaven National Laboratory Protein Data Bank. A method for synthesis of carbocyclic lexitropsins was elaborated, with the use of a nitro group or azobenzene as precursors for the aromatic amino group. The influence of methoxy group in ortho position with respect to amide groups on the activity of the new compounds was investigated. All of the compounds tested showed high antitumour activity in the standard cell line of mammalian tumour MCF-7.

Słowa kluczowe

EN

dimethyl sulphoxide; 4',6-diamidino-2-phenylindole; netropsin; tetramethylsilane; distamycin; antitumour activity; carbocyclic analogue; 4-[dimethylamino]pyridine; distamycin A

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 1
• Opis fizyczny: p.23-35,fig.

Twórcy

autor

Bartulewicz D.

• Medical Academy of Bialystok, Bialystok, Poland

autor

Markowska A.

autor

Wolczynski S.

autor

Dabrowska M.

autor

Rozanski A.

Bibliografia

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