Effects of pyrroline and pyrrolidine nitroxides on lipid peroxidation in heart tissue of rats treated with doxorubicin

• Autorzy: Koceva-Chyla A , Gwozdzinski K. , Kochman A. , Stolarska A. , Jozwiak Z.
• Języki publikacji: EN

Abstrakty

EN

Protection from doxorubicin-induced lipid peroxidation in vivo by two pyrroline and pyrrolidine nitroxides, Pirolin, PL, and Pirolid, PD, was examined in the heart tissue of rats treated with this drug. The level of lipid peroxidation was estimated on the basis of MDA content. A considerable (threefold) increase in the MDA amount was found in heart homogenates from rats injected with doxorubicin, whereas no significant changes in MDA content compared to control were observed in cardiomyocytes treated with the nitroxides (Pirolin or Pirolid) only. Pirolin injected simultaneously with doxorubicin showed antioxidative effect and markedly attenuated lipid peroxidation in the heart tissue caused by this drug. In contrast to Pirolin, structurally related Pirolid was ineffective in the protection of heart myocytes from DOX-induced lipid peroxidation.

Słowa kluczowe

EN

anthracycline drug; nitroxide; doxorubicin; protection; heart tissue; hart; lipid peroxidation; pirolin; cardiomyocyte; pirolid

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2003
• Tom: 08
• Numer: 1
• Opis fizyczny: p.179-183,fig.

Twórcy

autor

Koceva-Chyla A

• University of Lodz, Lodz, Poland

autor

Gwozdzinski K.

autor

Kochman A.

autor

Stolarska A.

autor

Jozwiak Z.

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