Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group

• Autorzy: Misiura K. , Wojcik M. , Krakowiak A. , Koziolkiewicz M. , Pawlowska Z. , Pluskota E. , Cierniewski C.S. , Stec W.J.
• Języki publikacji: EN

Abstrakty

EN

Dimethoxytritylphosphono-oligonucleotide conjugates have been prepared. They are totally resistant to nucleases present in human serum and do not affect cleavage of a complementary oligoribonucleotide by RNase H. Conjugates possessing a phosphate backbone gave better antisense inhibition of expression of plasminogen activator inhibitor type-1 within endothelial cells as compared with unconjugated oligonucleotides.

Słowa kluczowe

EN

ribonuclease H; human serum; plasminogen; nuclease; dimethoxytrityl group; oligonucleotide; activator inhibitor

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1998
• Tom: 45
• Numer: 1
• Opis fizyczny: p.27-32,fig.

Twórcy

autor

Misiura K.

• Polish Academy of Sciences, H.Sienkiewicza 112, 90-363 Lodz, Poland

autor

Wojcik M.

autor

Krakowiak A.

autor

Koziolkiewicz M.

autor

Pawlowska Z.

autor

Pluskota E.

autor

Cierniewski C.S.

autor

Stec W.J.

Bibliografia

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