Tuberculosis bacilli still posing a threat. Polymorphism of genes regulating anti-mycobacterial properties of macrophages

• Autorzy: Druszczynska M , Strapagiel D. , Kwiatkowska S. , Kowalewicz-Kulbat M. , Rozalska B. , Chmiela M. , Rudnicka W.
• Języki publikacji: EN

Abstrakty

EN

One third of the earth's population is infected with Mycobacterium tuberculosis, but only 5-10% of the infected individuals will develop active disease over their lifetime. To identify the genes responsible for the variation in the human susceptibility/resistance to tuberculosis (TB) we determined the polymorphisms of three genes crucial for the function of macrophages, in TB patients and healthy controls with no past history of TB. We found no association between the polymorphisms of the NRAMP-INT4, MBL (codons 52, 54, 57) and CD14-159 genes and TB in a Caucasian Polish population. However, we have suggested a possible involvement of CD14 and MBL molecules in the host-mycobacteria interactions on the basis of the significant increase in the serum CD14 and MBL in TB patients compared to healthy controls.

Słowa kluczowe

EN

polymorphism; macrophage; Mycobacterium tuberculosis; lung disease; tuberculosis; microbiology; human resistance; anti-mycobacterial property

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2006
• Tom: 55
• Numer: 1
• Opis fizyczny: p.7-12,fig.,ref.

Twórcy

autor

Druszczynska M

• University of Lodz, Banacha 12/16, 90-237 Lodz, Poland

autor

Strapagiel D.

autor

Kwiatkowska S.

autor

Kowalewicz-Kulbat M.

autor

Rozalska B.

autor

Chmiela M.

autor

Rudnicka W.

Bibliografia

• Baldini M., I.C. Lohman, M. Halonen, R.P. Erickson, P.G. Holt and F.D. Martinez. 1999. A polymorphism in the 5-prime flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am. J. Resp. Cell. Molec. Biol. 20: 976-983.
• Bellamy R., C. Ruwende, T. Corrah, K.P.W.J. McAdam, H.C. Whittle and A.V.S. Hill. 1998a. Variations in the NRAMP-1 gene and susceptibility to tuberculosis in West Africa. N. Engl. J. Med. 338: 640-644.
• Bellamy R., C. Ruwende, K.P.W.J. McAdam, M. Tursz, M. Sumiya, J. Summerfield, S.C. Gilbert, T. Corrah, D. Kwiatkowski, H.C. Whittle and A.V.S. Hill. 1998b. Mannose-binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. Q. J. Med. 91: 13-18.
• Bonar A., M. Chmiela and B. Różalska. 2004. Level of mannose-binding lectin (MBL) in patients with tuberculosis. Pneumonol. Alergol. Pol. 72: 201-205.
• Dye C, S. Scheele, P. Dolin, V. Pathania, M.C. Raviglione. 1999. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA. 282: 677-686.
• El Sahly H.M., R.A. Reich, S. Jun Dou, J.M. Musser and E.A. Graviss. 2004. The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups. Scand. J. Infect. Dis. 36: 106-108.
• Eng H.L, C.H. Wang, Ch. Chen, M.H. Chou, C.T. Cheng and T.M. Lin. 2004. A CD14 promoter polymorphism is associated with CD14 expression and Chlamydia-stivmilated TNFa production. Genes. Immun. 5: 426-430.
• Fitness J., S. Floyd, D.K. Warndorff, L. Sichali, S. Malema, A.C. Crampin, P.E. Fine and A.V. Hill. 2004. Large-scale candidate gene study of tuberculosis susceptibility in the Karonga district of northern Malawi. Am. J. Trop. Med. Hyg. 71: 341-349.
• Frehel C, F. Cannone-Hergaux, P. Gros and C. De Chastellier. 2002. Effect of Nrampl on bacterial replication and on maturation of Mycobacterium avium - containing phagosomes in bone marrow-derived macrophages. Cell. Microbiol. 4: 541-546.
• Garred P., C. Richter, A.B. Andersen, H.O. Madsen, I. Mtoni and A. Svejgaard. 1997. Mannan-binding lectin in the sub-Saharan HIV and tuberculosis epidemics. Scand. J. Immunol. 46: 204-208.
• LeBouder E., J.E. Rey-Nores, N.K. Rushmere, M. Grigorov, S.D. Lawn, M. Affolter, G.E. Griffin, P. Ferrara, E.J. Schiffrin, B.P. Morgan and M.O. Labeta. 2003. Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk. J. Immunol. 171: 6680-6689.
• Nadesalingam J., A.W. Dodds, K.B. Reid and N. Palaniyar. 2005. Mannose-binding lectin recognizes peptidoglican via the N-acetyl glucosamine moiety, and inhibits ligand-induced proinflammatory effect and promotes chemokine production by macrophages. J. Immunol. 175: 1785-1794.
• North R.J. and E. Medina. 1996. Significance of the antimycobacterial resistance gene, Nramp1, in resistance to virulent Mycobacterium tuberculosis infection. Res. Immunol. 147: 493-499.
• Pacheco E., C. Fonseca, C. Montes, J. Zabaleta, L.F. Garcia and M.A. Arias. 2004. CD14 gene promoter polymorphism in different forms of tuberculosis. FEMS Immunol. Med. Microbiol. 40: 207-213.
• Paziak-Domańska B., A. Bonar, M. Kowalewicz-Kulbat, M. Klink, M. Kowalski, J. Karhukorpi, R. Karttunen, M. Jurkiewicz, B. Różalska and W. Rudnicka. 2002. The lack of relationship between serum content of MBL, sCD14, anti-PPD and anti-Hsp65 IgG and ingestion of M. bovis BCG bacilli by phagocytes. Arch. Immunol. Ther. Exp. 50: 337-344.
• Selvaraj P., P.R. Narayanan and A.M. Reetha. 1999. Association of the functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India. Tuber. Lung Dis. 79: 221-227.
• Søborg Ch., A.B. Andersen, H.O. Madsen, A. Kok-Jensen, P. Skinhøj and P. Garred. 2002. Natural-resistance-associated macrophage protein 1 polymorphism are associated with microscopy-positive tuberculosis. J. Infect. Dis. 186: 517-521.
• Turner M.W. 2003. The role of mannose-binding lectin in health and disease. Mol. Immunol. 40: 423-429.
• WHO Global Tuberculosis Control Surveillance, Planning, Finansing. WHO Report 2004. Geneva, Switzerland.