The role of IL-6 in mediating the anti-inflammatory effects of exercise

• Autorzy: Petersen A.M.W. , Pedersen B.K.
• Języki publikacji: EN

Abstrakty

EN

Regular exercise offers protection against all cause mortality and there is evidence from randomised intervention studies that physical training is effective as a treatment in patients with chronic heart diseases, type 2 diabetes and symptoms related to the metabolic syndrome. Chronic diseases such as cardiovascular disease, type 2 diabetes and cancer are associated with chronic low-grade systemic inflammation. It has been demonstrated that regular exercise induces anti-inflammatory effects with elevated levels of anti-inflammatory cytokines and suppression of TNF-alpha production. Thereby, exercise offers protection against TNF-alpha-induced insulin resistance. Otherwise, the exercise-induced production and release of IL-6 from myofibers may contribute to abrogate an atherogenic lipid profile, which is often associated with chronic diseases. This review focuses on the anti-inflammatory effects of exercise and how this may contribute to mediate the beneficial health effects of exercise training in patients with chronic diseases associated with chronic low-grade inflammation.

Słowa kluczowe

EN

interleukin 6; antiinflammatory effect; exercise; chronic heart disease; diabetes type 2; cardiovascular disease; metabolic syndrome; cancer; antiinflammatory cytokine; cytokine; supression; tumour necrosis factor-alpha; insulin resistance; atherosclerosis

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2006
• Tom: 57
• Numer: 10
• Opis fizyczny: p.43-51,ref.

Twórcy

autor

Petersen A.M.W.

• University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

autor

Pedersen B.K.