Identification of 2-[2-nitro-4-[trifluoromethyl]benzoyl]-cyclohexane-1,3-dione metabolites in urine of patients suffering from tyrosinemia type I with the use of1H and 19F NMR spectroscopy

• Autorzy: Szczecinski P. , Lamparska D. , Gryff-Keller A. , Gradowska W.
• Języki publikacji: EN

Abstrakty

EN

Organic extracts of six urine samples from children treated with nitisinone, a medicine against tyrosinemia type I, were investigated by 1H and 19F NMR spectroscopy. The presence of unchanged 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC), 6-hydroxy-2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC-OH) and 2-nitro-4-trifluoromethylbenzoic acid (NTFA) as well as a few other unidentified compounds containing CF3 group was documented.

Słowa kluczowe

PL

metabolite; 2-[2-nitro-4-trifluoromethyl]benzoyl]-cyclohexane-1,3-dione metabolite; identification; patient; urine; tyrosinemia type I; NMR method; child; urine sample

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2008
• Tom: 55
• Numer: 4
• Opis fizyczny: p.749-752,fig.,ref.

Twórcy

autor

Szczecinski P.

• Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

autor

Lamparska D.

autor

Gryff-Keller A.

autor

Gradowska W.

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