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Tytuł artykułu

Rola szczepien szczepionkami delecyjnymi w ograniczaniu rozprzestrzeniania wirusa choroby Aujeszkyego w fermach swin objetych programem "szczepienie - eliminacja"

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Języki publikacji

PL

Abstrakty

EN
Vaccinations play an important role in the control of Aujeszky’s disease (AD) because they interrupt the chain of piglet morbidity and mortality as well as decreasing the spread of Herpesvirus suis type 1 (SHV-1). Conventional vaccines, however, preclude serological differentiation between vaccinated and SHV-1 infected pigs. Such differentiation has only become possible after the creation of deleted (marker) vaccines, which, together with the appropriate serological tests (ELISA), have enabled the realisation of a „vaccination - eradication programme” and presented a new perspective on AD eradication in those countries where pigs are vaccinated. The purpose of this study was to evaluate the influence of an intensive vaccination programme using deleted vaccine in decreasing the spread of SHV-1 in two highly infected pig farms covered in the „vaccination - eradication programme”. All the pigs were vaccinated with deleted, gE- and TK-negative, live attenuated Nobi - Porvac Aujeszky Live Begonia (at present Porcilis Begonia) vaccine - Intervet Int. Holland according to its accepted programme: reproductive pigs 4 months apart and fattening pigs twice at 10-12 and 14-16 week of age. Control serological examinations with gE-ELISA using CHEKIT-PRV-gl-EIA, dr Bommeli AG, Switzerland were performed. In groups of sows a gradual, slow decrease of SHV-1 infection rates from 100% before vaccination to 60% in farm R and 41.7% in farm В after the 4th re-vaccination were observed. A more rapid decrease of SHV-1 infection rates among fattening pigs - from 90% to 10% after 13 months and 0% after the 19 month of herd vaccinations in farm R, and from 80% to 0% as early as after 7 months of herd vaccination in farm В were observed. Serological examinations of all sows and boars after 2.5 years of herd vaccination revealed a decrease of SHV-1 infection rates from 100% to 34,9% in farm R and 28.2% in farm В respectively. This demonstrated that appropriately prepared and consequently realised vaccination programmes of all pigs, using a good quality deleted vaccine, radically decreases the spread of virulent SHV-1 virus in infected herds. The possibilities of serological differentiation between immunised and infected pigs combined with a natural rotation of infected reproductive pigs and, next, with an appropriate and properly conducted, economically viable elimination of seropositives creates a realistic chance of eliminating virulent SHV-1 even from highly infected swine herds.

Wydawca

-

Rocznik

Tom

56

Numer

04

Opis fizyczny

s.229-234,tab.,bibliogr.

Twórcy

autor
  • Uniwersytet Warminsko-Mazurski, ul. Oczapowskiego 13, 10-957 Olsztyn
autor
autor
autor
autor

Bibliografia

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  • 4. Gielkens A. L. J., Van Oirschot J. T, Berns A. J. Mr. Genome differences among field isolates and vaccine strains of pseudorabies virus. J. Gen. Virol. 1985, 66, 69-82.
  • 5. Gielkens A. L. J., Moormann J. M, Van Oirschot J. T, Berns A. J. Mr. Vaccine efficacy and innocuity of strain 783 of Aujeszky’s disease virus. Curr. Top. Med. Anim. Sci. 1989, 49, 27-35.
  • 6 .Jacobs L„ Mulder W. A. M., Priem J., PolJ. M. A.. Kimman T. GGlycoprotein I of pseudorabies virus (Aujeszky’s disease virus) determines virulence and facilitates penetration of the virus into the central nervous system of pigs. Acta Vet. Hung. 1994, 42, 289-300.
  • 7 .Kritas S. K., Pensaert M. B., Mettenleiter M. C.: Invasion and spread of single glycoprotein deleted mutants of Aujeszky’s disease virus (ADV) in the trigeminal nervous pathway of pigs after intranasal inoculation. Vet. Microbiol. 1994, 40, 323-334.
  • 8. Lehman J. R„ Weigel R. M„ Siegel A. M, Herr L. G., Taft A. C„ Hall W. F: Progress after one year of a pseudorabies eradication program from large swine herds. J. Am. Vet. Med. Ass. 1993, 203, 118-121.
  • 9. Maes R. K„ Schutz J. CEvaluation in swine of a subunit vaccine against pseudorabies. Am. J. Vet. Res. 1983, 44. 123-125.
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  • 12. Mengeling W. L„ Lager K. M„ Volz D. M, Brockmeier S. Lr. Effect of various vaccination procedures on shedding, latency and reactivation of attenuated and virulent pseudorabies virus in swine. Am. J. Vet. Res. 1992, 53, 2164-2173.
  • 13. Mock R. E., Crandell R. A., Mesfin G. Mr. Induced latency in pseudorabies vaccinated pigs. Can. J. comp. Med. 1981, 45, 56-59.
  • 14. Pensaert M. B., De Smet К., De Waele Kr. Extent and duration of virulent virus excretion upon challange of pigs vaccinated with different glycoprotein - deleted Aujeszky’s disease virus. Vet. Microbiol. 1990, 22, 107-117.
  • 15.Platt K. Br. The evaluation of a lectin - agarose based subunit vaccine and complementary diagnostic antigen for Aujeszky’s disease (pseudorabies) in the pig. Vet. Microbiol. 1984, 9, 35-51.
  • 16. Quint W., Gielkens A. L. J., Van Oirschot J. T, Berns A. J. M„ CuypersH. Tr. Construction and characterization of deletion mutants of pseudorabies virus: a new generation of “live” vaccines. J. Gen. Virol. 1987, 68, 523-534.
  • 17.Stegeman A., Kimman T. G., Van Oirschot J. I, Tielen M. J. M, Hunneman W. A.: Spread of Aujaszky s disease virus within pig herds in an intensively vaccinated region. Vet. Rec. 1994, 134, 327-330.
  • 18.Stegeman A., Tielen M. J. M, Kimman T. G., Van Oirschot J. I, Hunneman W. A., Berndsen F. Wr. Intensive regional vaccination with a gE-deleted vaccine markedly reduces pseudorabies virus infections. Vaccine 1994, 12,527- -531.
  • 19.Stegeman A., Van Oirschot J. I, Kimman T. G., Tielen M. J. M, Hunneman W. A.. Berndsen F. Wr. Reduction of the prevalence of pseudorabies virus - infected breeding pigs by use of intensive regional vaccination. Am. J. Vet. Res. 1994, 55, 1381-1385.
  • 20.Stegeman A., Elbers A. R. W., Van Oirschot J. I, Hunneman W. A., Kimman T. G., Tielen M. J. Mr. A retrospective study into characteristics associated with the seroprevalence of pseudorabies virus - infected breeding pigs in vaccinated herds in the Southern Netherlands. Prev. Vet. Med. 1995, 22, 273-283.
  • 21. Stegeman A., Elbers A. R., De Jong M. С. M., Oosterlaak B., Dijkhuizen A. A.: Estimating the rate of pseudorabies virus introduction into pig - finishing herds at regional level. Vet. Quart. 1997, 19, 5-9.
  • 22. Szweda Wr. Badania nad zastosowaniem różnych metod zapobiegania i zwalczania choroby Aujeszkyego u trzody chlewnej. Praca hab., Wydz. Medycyny Weterynaryjnej, ART Olsztyn, 1992.
  • 23. Szweda W, Lipowski A., Bączek W.. Dadun Mr. Kształtowanie się odporności humoralnej w stadach świń immunizowanych szczepionką delecyjnąprzeciw chorobie Aujeszkyego. Mat. X Kongresu PTNW, Wrocław 1996, t. 2/3, s. 432.
  • 24. Vannier P, Le Foli Pr. Les grandes maladie virales contagieuses du porc: Situation epidemiologique en France et en Europe. J. Rech. Proc., France 1988, 20, 73-82.
  • 25. Vannier P. Eliot M. E., Gouello L., La Bail P, Toma Br. Epidemiological studies of the persistence of Aujeszky’s disease virus between and within herds in France. Prev. Vet. Med. 1991, 11, 115-123.
  • 26. Vannier P, Hutet E., Bourgueil E., Cariolet R.: Level of virulent virus excreted by infected pigs previously vaccinated with different glycoprotein deleted Aujeszky’s disease vaccines. Vet. Microbiol. 1991, 29, 213-223.
  • 27. Van Oirschot J. T, Gielkens A. L. Jr. Latency of virulent Aujeszky’s disease virus in pigs is not prevented by passive or active immunization. Curr. Top. Vet. Med. Anim. Sci. 1984, 27, 417-427.
  • 28. Van Oirschot J. T, Rziha H. J.. Moonen L. M„ Pol J. M. A., Van Zaane Dr. Aujeszky’s disease: Infected pigs can be distinguished from vaccinated pigs. Proc., 9th IPVS Congress, Barcelona 1986, s. 355.
  • 29. Van Oirschot J. T, De Waal C. A. Hr. An ELISA to distinguish between Aujeszky’s disease vaccinated and infected pigs: First experience with its use in a vaccinated herd. Vet. Rec. 1987, 121, 305-306.
  • 30. Van Oirschot J. T.: The antibody response to glycoprotein I and the control of Aujeszky’s disease. Curr. Top. Vet. Med. Anim. Sci. 1989, 49, 129-138.
  • 31. Van Oirschot J. T, Oei H. Lr Comparison of two ELISA for detecting antibodies to glycoprotein I of Aujeszky’s disease virus. Vet. Rec. 1989, 125,63- -64.
  • 32. Van Oirschot J. T, Gielkens A. L. J., Moormann R. J. M, Berns A. J. Mr. Marker vaccines, virus protein - specific antibody assays and the control of Aujeszky’s disease. Vet. Microbiol. 1990, 23, 85-101.
  • 33. Van Oirschot J. T, Wijsmuller J. M., De Waal С. A. H„ Van Lith P. Mr. A novel concept for the control of Aujeszky’s disease: Experiences in two vaccinated pig herds. Vet. Rec. 1990, 126, 159-163.
  • 34. Visser N., Liitticken D.: Experiences with a gl /ТК modified live pseudorabies virus vaccine: strain Begonia. Curr. Top. Vet. Med. Anim. Sci. 1988,49, 37-44.
  • 35. Visser Nr. Vaccination strategies for improving the efficacy of programs to eradicate Aujeszky’s disease virus. Vet. Microbiol. 1997, 55, 61-74.
  • 36. Wittmann G., Ohlinger V., Hohn Ur. Die Vermehrung von Aujeszky virus (AV) in vakzinierten Schweinen nad experimenteller Infection mit hohen und niederen Virusmengen. Zbl. Vet. Med. В 1982, 29, 24-30.
  • 37. Wittmann G„ Ohlinger V, Rziha H. Jr. Occurence and reactivation of latent Aujeszky’s disease virus following challenge in previously vaccinated pigs. Arch. Virol. 1983, 75, 29-41.
  • 38. Wittmann Gr. Aujeszky’s disease: factors important for epizootiology and control. Proc. 11th Conf. OIE Reg. Comm. Eur., Vienna, Austria 1984, s. 3.

Typ dokumentu

Bibliografia

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