Molecular mechanisms of cancer-preventive effects of garlic organosulfur compounds

• Autorzy: Turek S
• Języki publikacji: EN

Abstrakty

EN

Pharmacological activity of garlic (Allium sativum L.) has been thoroughly evaluated for many years. The development of modern techniques in phytochemical analysis has ena­bled to detect a broad spectrum of organosulfur compounds which have an interesting biological activity. Recently, inhibition of carcinogenesis, observed at many stages, has seemed to be the most important feature. It has been established that garlic organosul­fur compounds can inhibit cancer development through multiple mechanisms, including mostly: modulating activity of carcinogen-metabolising enzymes, direct antiradical activi­ty, inhibiting cell proliferation and promoting apoptosis.

PL

Od dawna bada się aktywność farmakologiczną czosnku zwyczajnego (Allium sativum L.), ale dopiero zastosowanie nowoczesnych metod w analizie fitochemicznej tego sur­owca pozwoliło zidentyfikować całą gamę organicznych związków siarki o znaczącym działaniu farmakologicznym. W ostatnich latach dużą uwagę zwraca szczególnie szeroki zakres aktywności przeciwnowotworowej. Badania dowodzą, że związki siarki zawarte w czosnku wpływają na różne etapy karcynogenezy, hamując rozwój nowotworu ple- jotropowo. Działanie przeciwnowotworowe tych związków polega przede wszystkim na modyfikacji aktywności układu enzymów detoksyfikacyjnych pierwszej i drugiej fazy, bezpośredniej aktywności przeciwwolnorodnikowej oraz wpływie na procesy apoptozy i proliferacji komórkowej.

Słowa kluczowe

EN

garlic; molecular mechanism; efficacy; organosulphur compound; carcinogenesis; free radical; apoptosis; cancer prevention

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2005
• Tom: 51
• Numer: 1-2
• Opis fizyczny: p.77-92,fig.,ref.

Twórcy

autor

Turek S

• Wroclaw Medical University, pl.Nankiera 1, 50-140 Wroclaw, Poland

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