PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2004 | 11 | 2 |
Tytuł artykułu

Age- and BMD-related differences in biochemical markers of bone metabolism in rural and urban women from Lublin Region, Poland

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The utility of biochemical markers of bone metabolism has not been proven in the diagnosis of metabolic diseases of the bone tissue; however they are widely used as a tools for treatment monitoring. Their serum concentrations are influenced by a number of factors, like gender, health status, anthropometric and environmental factors. All the factors listed above should be taken into consideration during clinical use. The aim of the study was to determine the reference values and evaluate the influence of environmental and anthropometric variables on biochemical markers of bone turnover for women from Lublin Region (Poland). Subjects of the study were 188 normal women aged 30-79, all residents of Lublin Region. Analysed markers of bone turnover were: osteocalcin (OC) and C-terminal cross-linking telopeptide of type I collagen (CTX-I), both assessed using ELISA method. All blood samples were taken and analyzed at the Clinical Chem. Laboratory and Patho-morphology Department at the Institute of Agricultural Medicine in Lublin. The lumbar spine (L2-L4) of all subjects was examined in a-p position using the dual X-ray absorptiometry-DXA (DPX-A LUNAR Corp.) at the Department of Metabolic and Degenerative Diseases of Bone Tissue of Institute of Agricultural Medicine in Lublin. Data pertaining to factors affecting bone tissue were collected using a specially prepared questionnaire. Serum levels of OC and CTX-I in women in every age range were different, generally increasing with age. Serum levels of OC and CTX-I in the analysed population strongly depended of both menopausal status and bone mineral density. In conclusion, this study demonstrates that age and menopausal status variations need to be considered when interpreting laboratory measurements of biochemical markers of bone metabolism.
Wydawca
-
Rocznik
Tom
11
Numer
2
Opis fizyczny
p.255-259,ref.
Twórcy
autor
  • Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland
autor
Bibliografia
  • 1. Adachi JD: The correlation of bone mineral density and biochemical markers to fracture risk. Calcif Tissue Int 1996, 59, 16-19.
  • 2. Adami S, Passeri M, Ortolani S, Broggini M, Carratelli L, Caruso I, Gandolini G, Gnessi L, Laurenzi M, Lombardi A, et al.: Effects of oral alendronate and intranasal salmon calcitonin on bone mass and biochemical markers of bone turnover in postmenopausal women with osteoporosis. Bone 1995, 17, 383-390.
  • 3. Anim-Nyame N, Sooranna SR, Jones J, Alaghband-Zadeh J, Steer PJ, Johnson MR: A longitudinal study of biochemical markers of bone turnover during normal pregnancy and pregnancies complicated by preeclampsia. BJOG 2002, 109, 708-713.
  • 4. Bikle DD: Biochemical markers in the assessment of bone disease. Am J Med 1997, 103, 427-436.
  • 5. Bouillon R, Bex M, Van Herck E, Laureys J, Dooms L, Lesaffre E, Ravussin E: Influence of age, sex, and insulin on osteoblast function: osteoblast dysfunction in diabetes mellitus. J Clin Endocrinol Metab 1995, 80, 1194-1202.
  • 6. Calvo MS, Eyre DR, Gundberg CM: Molecular basis and clinical application of biological markers of bone turnover. Endocr Rev 1996, 17(4), 333-368.
  • 7. Crandall C: Parathyroid hormone for treatment of osteoporosis. Arch Intern Med 2002, 162, 2297-2309.
  • 8. Deftos LJ, Olfert RL, Hill CS: Bone alkaline phosphatase in Pagets disease. Horm Metab Res 1991, 23, 559-561.
  • 9. Dennison E, Eastell R, Fall CHD, Kellingray S, Wood PJ, Cooper C: Determinants of bone loss in elderly men and women: A prospective population based study. Osteopor Int 1999, 10, 384-391.
  • 10. De Leo V, Ditto A, la Marca A, Lanzetta D, Massafra C, Morgante G: Bone mineral density and biochemical markers of bone turnover in per- and postmenopausal women. Calcif Tissue Int 2000, 66, 263-267.
  • 11. Devogelaer JP, Broll H, Correa-Rotter R, Cumming DC, De Deuxchaisnes CN, Geusens P, Hosking D, Jaeger P, Kaufman JM, Leite M, Leon J, Liberman U, Menkes CJ, Meunier PJ, Reid I, Rodriguez J, Romanowicz A, Seeman E, Vermeulen A, Hirsch LJ, Lombardi A, Plezia K, Santora AC, Yates AJ, Yuan W: Oral alendronate induces progressive increases in bone mass of the spine, hip and total body over 3 years in postmenopausal women with osteoporosis. Bone 1996, 18, 141-150.
  • 12. Eastell R, Delmas PD, Hodgson SF, Mann KG, Riggs BL: Bone formation rate in older normal women: Concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers. J Clin Endocrinol Metab 1988, 67, 741-748.
  • 13. Ebeling PR, Atley LM, Guthrie JR, Burger HG, Dennerstein L, Hopper JL, Wark JD: Bone turnover markers and bone density across the menopausal transition. J Clin Endocrinol Metab 1996, 81, 3366-3371.
  • 14. Eriksen EF, Melsen F, Sod E, Barton I, Chines A: Effect of longterm risendronate on bone turnover in women with postmenopausal osteoporosis. Bone 2002, 31, 620-625.
  • 15. Finkelstein JS, Sowers M, Greendale GA, Lee MT, Neer RM, Cauley JA, Ettinger B: Ethnic variation in bone turnover in pre- and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 2002, 87, 3051-3056.
  • 16. Fohr B, Dunstan CR, Seibel M: Clinical review 165: Markers of bone remodeling in metastatic bone disease. J Clin Endocrinol Metab 2003, 88, 5059-5075.
  • 17. Garnero P, Mulleman D, Munoz F, Sornay-Rendu E, Delmas PD: Long term variability of markers of bone turnover in postmenopausal women and implications for their clinical use: the OFELY study. J Bone Mineral Res 2003, 18, 1789-1094.
  • 18. Garnero P, Sornay-Rendu E, Chaupuy MC, Delmas PD: Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 1996, 11, 337-349.
  • 19. Garnero P, Delmas PD: New developments in biochemical markers for osteoporosis. Calcif Tissue Int 1996, 59, 2-9.
  • 20. Guerrero R, Diaz Martin MA, Diaz Diego EM, Rapado A, de la Pietra C: New biochemical markers of bone resorption derived from collagen breakdown in the study of postmenopausal osteoporosis. Osteoporosis Int 1996, 6, 297-302.
  • 21. Gundberg CM, Looker AC, Nieman SD, Calvo MS: Paterns of osteocalcin and bone specific alkaline phosphatase by age, gender, and race or ethnicity. Bone 2002, 31, 703-708.
  • 22. Han ZH, Palnitkar S, Sudhaker Rao D, Nelson D, Parfitt AM: Effect of ethnicity and age of menopause on the remodelling and turnover of iliac bone: Implications for mechanisms of bone loss. J Bone Miner Res 1997, 12, 498-508.
  • 23. Henry YM, Eastell R: Ethnic and gender differences in bone mineral density and bone turnover in young adults: effect of bone size. Osteopor Int 2000, 11, 512-517.
  • 24. Hochberg MC, Greenspan S, Wasnich RD, Miller P, Thompson DE, Ross PD: Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab 2002, 87, 1586-1592.
  • 25. Johnel O, Scheele WH, Lu Y, Reginster JY, Need AG, Seeman E: Additive effects of raloxifene and alendronate on bone density and biochemical markers of bone remodeling in postmenopausal women with osteoporosis. J Clin Endocrinol Metab 2002, 87, 965-992.
  • 26. Kleerekoper M, Nelson DA, Peterson EL, Wilson PS, Jacobsen G, Longcope C: Reference data for bone mass, calciotropic hormones, and biochemical markers of bone remodeling in older (55-75) postmenopausal white and black women. J Bone Miner Res 1994, 9, 1267-1276.
  • 27. Krall EA, Dawson-Huges B, Hirst K, Gallager JC, Sherman SS, Dalsky G: Bone mineral density and biochemical markers of bone turnover in healthy elderly men and women. J Gerontol Med Sci 1997, 52A, 61-67.
  • 28. Kushida K, Takahashi M, Kawana K, Inoue T: Comparison of markers for bone formation and resorption in premenopausal and postmenopausal subjects, and osteoporosis patients. J Clin Endocrinol Metab 1995, 80, 2447-2450.
  • 29. Mansson B, Carey D, Alini M, Ionescu M, Rosenberg LC, Poole AR, Heinegard D, Saxne T: Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J Clin Invest 1995, 95(3), 1071-1077.
  • 30. Matsukura T, Kagamimori S, Nishino H, Yamagami T, Iki M, Kajita E, Kagawa Y, Yoneshima H, Matsuzaki T, Marumo F: The characteristics of bone turnover in the second decade in relation to age and puberty development in healthy Japanese male and female subjects. Japanese Population-based Osteoporosis Study. Ann Human Biol 2003, 30, 13-25.
  • 31. Melton LJ, Khosla S, Atkinson EJ, O’Connor MK, O’Fallon WM, Riggs BL: Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteopor Int 2000, 11, 592-599.
  • 32. Melton LJ, Khosla S, Atkinson EJ, O’Fallon WM, Riggs BL: Relationship of bone turnover to bone density and fractures. J Bone Miner Res 1997, 12, 1083-1091.
  • 33. Rauch F, Schonau E, Woitge H, Remer T, Seibel M: Urinary excretion of hydroxy-pyridinium cross-links of collagen reflects skeletal growth velocity in normal children. Exp Clin Endocrinol 1994, 102, 94-97.
  • 34. Reid IR, Brown JP, Burckhardt P, Horowitz Z, Richardson P, Trechsel U, Widmer A, Devogelaer JP, Kaufman JM, Jaeger P, Body JJ, Brandi ML, Broell J, Di Micco R, Genazzani AR, Felsenberg D, Happ J, Hooper MJ, Ittner J, Leb G, Mallmin H, Murray T, Ortolani S, Rubinacci A, Saaf M, Samsioe G, Verbruggen L, Meunier PJ: Intravenous zoledronic acid in postmenopausal women with low bone mineral density. N Engl J Med 2002, 346, 653-661.
  • 35. Rudnicki M, Thode J, Jorgensen T, Heitman BL: Effects of age, sex, season, and diet on serum ionized calcium, parathyroid hormone and vit. D in random population. J Intern Med 1993, 234, 195-200.
  • 36. de la Piedra C, Traba ML, Cabera DC, Henriques MS: New biochemical markers of bone resorption in the study of pomenopausal osteoporosis. Clin Chim Act 1997, 265, 225-234.
  • 37. Sherman SS, Hollis BW, Tobin JD: Vitamin D status and related parameters in a healthy population: The effect of age, sex, and season. J Clin Endocrinol Metab 1990, 71, 405-413.
  • 38. Sone T, Miyake M, Takeda N, Fukunaga M: Urinary excretion of type I collagen crosslinked N-telopeptides in healthy Japanese adults: age- and sex-related changes and reference limits. Bone 1995, 17, 335-339.
  • 39. Sorensen OH, Crawford GM, Mulder H, Hosking DJ, Gennari C, Mellstrom D, Pack S, Wenderoth D, Cooper C, Reginster JY: Long-term efficacy of risedronate: a 5-year placebo-controlled clinical experience. Bone 2003, 32, 120-126.
  • 40. Sowers M, Eyre D, Hollis BW, Randolph JF, Shapiro B, Jannausch ML, Crutchfield M: Biochemical markers of bone turnover in lactating and nonlactating postpartum women. J Clin Endocrinol Metab 1995, 80, 2210-2029.
  • 41. Tsai KS, Pan WH, Hsu SJH: Sexual difference in bone markers and b one mineral density in normal Chinese. Calcif Tissue Int 1996, 59, 454-460.
  • 42. Woitge HW, Scheigt-Nave C, Kissling C, Leidig-Bruckner G, Meyer K, Grauer A, Scharla SH, Ziegler R, Seibel MJ: Seasonal variation of biochemical indexes of bone turnover: results of a population based study. J Clin Endocrinol Metab 1998, 83, 68-75.
  • 43. Vergnaud P, Garnero P, Meunier PJ, Breart G, Kamihagi K, Delmas PD: Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: The EPIDOS study. J Clin Endocrinol Metab 1997, 82, 719-724.
  • 44. Yan L, Prentice A, Zhou B, Zhang H, Wang X, Stirling DM, Laidlaw A, Han Y, Laskey A: Age- and gender-related differences in bone mineral status and biochemical markers of bone metabolism in Northern Chinese men and women. Bone 2002, 30, 412-415.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-article-75020a3c-0185-47b4-bc8e-be7b4ba69756
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.