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2007 | 54 | 2 |

Tytuł artykułu

Dynamics of estrogen-induced oxidative stress

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.

Wydawca

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Rocznik

Tom

54

Numer

2

Opis fizyczny

p.289-295,fig.,ref.

Twórcy

autor
  • Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland
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Bibliografia

  • Aggarwal BB, Ichikawa H (2005) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4: 1201–1215.
  • American Cancer Society (2001) Cancer Facts and Figs. American Cancer Society, Atlanta, Georgia.
  • Bellomo G, Vairetti M, Stivala L, Mirabelli F, Richelmi P, Orrenius S (1992) Demonstration of nuclear compartmentalization of glutathione in hepatocytes. Proc Natl Acad Sci USA 89: 4412–4416.
  • Bowcock A (1999) Breast Cancer. Humana Press, Clifton, NJ.
  • Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL (2000) A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chem Res Toxicol 13: 342–350.
  • Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikolic D, Bolton JL (1998) The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chem Res Toxicol 11: 1105–1111.
  • Cooke MS, Olinski R, Evans MD (2006) Does measurement of oxidative damage to DNA have clinical significance? Clin Chim Acta 365: 30–49.
  • Du J, Gebicki JM (2002) DNA degradation and protein peroxidation in cells exposed to hydroxyl free radicals. Redox Rep 7: 329–331.
  • Foksinski M, Bialkowski K, Skiba M, Ponikowska I, Szmurlo W, Olinski R (1999) Evaluation of 8–oxodeoxyguanosine, typical oxidative DNA damage, in lymphocytes of ozone-treated arteriosclerotic patients. Mutat Res 438: 23–27.
  • Friedberg EC, Walker GC, Siede W (1995) DNA Repair and Mutagenesis. American Society for Microbiology, Washington, DC.
  • Gackowski D, Kruszewski M, Bartlomiejczyk T, Jawien A, Ciecierski M, Olinski R (2002) The level of 8–oxo-7,8–dihydro-2’-deoxyguanosine is positively correlated with the size of the labile iron pool in human lymphocytes. J Biol Inorg Chem 7: 548–550.
  • Gautier JC, Holzhaeuser D, Markovic J, Gremaud E, Schilter B, Turesky RJ (2001) Oxidative damage and stress response from ochratoxin a exposure in rats. Free Radic Biol Med 30: 1089–1098.
  • Gebicki S, Gebicki JM (1999) Crosslinking of DNA and proteins induced by protein hydroperoxides. Biochem J 338: 629–636.
  • Hashimoto R, Narita S, Yamada Y, Tanaka K, Kojo S (2000) Unusually high reactivity of apolipoprotein B-100 among proteins to radical reactions induced in human plasma. Biochim Biophys Acta 1483: 236–240.
  • Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR (1996) 17α-Estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci USA 93: 9776–9781.
  • Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L (2000) Tissue-specific synthesis and oxidative metabolism of estrogens. J Natl Cancer Inst Monogr 27: 95–112.
  • Kim JG, Sabbagh F, Santanam N, Wilcox JN, Medford RM, Parthasarathy S (1997) Generation of a polyclonal antibody against lipid peroxide-modified proteins. Free Radic Biol Med 23: 251–259.
  • Krajowy Rejestr Nowotworów Centrum Onkologii-Instytut im. M. Skłodowskiej-Curie (2003) Nowotwory złośliwe w Polsce w 2000 roku. Warszawa (in Polish).
  • Kobiela J, Krajewski J, Kalinska-Blach B, Stefaniak T (2002) Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis. Acta Biochim Polon 49: 51–58.
  • Lebovitz RM, Zhang H, Vogel H, Cartwright J Jr, Dionne L, Lu N, Huang S, Matzuk MM (1996) Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 93: 9782–9787.
  • Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase, Nat Genet 11: 376–381.
  • Luxford C, Morin B, Dean RT, Davies MJ (1999) Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA. Biochem J 344: 125–134.
  • Malins DC, Haimanot R (1991) Major alterations in the nucleotide structure of DNA in cancer of the female breast. Cancer Res 51: 5430–5432.
  • Malins DC, Holmes EH, Polisssar NL, Gunselman SJ (1993) The etiology of breast cancer. Characteristic alterations in hydroxyl radical-induced DNA base lesions during oncogenesis with potential for evaluating incidence risk. Cancer 17: 3036–3043.
  • Matsui A, Ikeda T, Enomoto K, Hosoda K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M (2000) Increased formation of oxidative DNA damage, 8-hydroxy-2’-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett 151: 87–95.
  • Mobley JA, Brueggemeier RW (2002) Increasing the DNA damage threshold in breast cancer cells. Toxicol Appl Pharmacol 180: 219–226.
  • Molinari AM, Bontempo P, Schiavone EM, Tortora V, Verdicchio MA, Napolitano M, Nola E, Moncharmont B, Medici N, Nigro V, Armetta I, Abbondanza C, Puca GA (2000) Estradiol induces functional inactivation of p53 by intracellular redistribution. Cancer Res 60: 2594–2597.
  • Musarrat J, Arezina WJ, Wani AA (1996) Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer 32: 1209–1214.
  • Oliver CN, Ahn BW, Moerman EJ, Goldstein S, Stadtman ER (1987) Age-related changes in oxidized proteins. J Biol Chem 262: 5488–5491.
  • Olinski R, Siomek A, Rozalski R, Gackowski D, Foksinski M, Guz J, Dziaman T, Szpila A, Tudek B (2007) Oxidative damage to DNA and antioxidant status in aging and age-related diseases. Acta Biochim Polon 54: 11–26.
  • Refsgaard HH, Tsai L, Stadtman ER (2000) Modifications of proteins by polyunsaturated fatty acid peroxidation products. Proc Natl Acad Sci USA 97: 611–616.
  • Renke J, Popadiuk S, Korzon M, Bugajczyk B, Wozniak M (2000) Protein carbonyl groups’ content as a useful clinical marker of antioxidant barrier impairment in plasma of children with juvenile chronic arthritis. Free Radical Biol Med 29: 101–104.
  • Roy D, Liehr JG (1999) Estrogen, DNA damage and mutations. Mutat Res 424: 107–115.
  • Schnurr K, Hellwing M, Seidemann B, Jungblut P, Kuhn H, Rapoport SM, Schewe T (1996) Oxygenation of biomembranes by mammalian lipoxygenases: The role of ubiquinone. Free Radical Biol Med 20: 11–21.
  • Schreier S, Polnaszek CF, Smith IC (1978) Spin labels in membranes. Problems in practice. Biochim Biophys Acta 515: 395–436.
  • Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, van Breemen RB, Bolton JL (1997) Bioreductive activation of catechol estrogen-ortho-quinones: Aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity. Carcinogenesis 18: 1093–1101.
  • Spink DC, Eugster HP, Linclon DW, Schuetz JD, Schuetz EG, Johnson JA, Kaminsky LS, Gierthy JF (1992) 17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. Arch Biochem Biophys 293: 342–348.
  • Spink DC, Hayes CL, Young NR, Christou M, Sutter TR, Jefcoate CR, Gierthy JF (1994) The effects of 2,3,7,8-tetra-chlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17α-estradiol 4-hydroxylase. J Steroid Biochem Mol Biol 51: 251–258.
  • Spink DC, Spink BC, Cao JQ, DePasquale JA, Pentecost BT, Fasco MJ, Li Y, Sutter TR (1998) Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. Carcinogenesis 19: 291–298.
  • Stefaniak T, Krajewski J, Kobiela J, Makarewicz W, Stanek A, Asano M, Kondo R, Wakabayashi T, Gruca Z, Wozniak M (2002) Protein oxidation in male Syrian hamster kidney during estrogen-induced carcinogenesis. Pathophysiology 8: 269–273.
  • Thomas PD, Poznansky MJ (1990) A modified tetra-methylbenzidine method for measuring lipid hydroperoxides. Anal Biochem 188: 228–232.
  • Tsai L, Szweda PA, Vinogradova O, Szweda LI (1998) Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2–nonenal and lysine. Proc Natl Acad Sci USA 95: 7975–7980.
  • Wellejus A, Loft S (2002) Receptor-mediated ethinylestradiol- induced oxidative DNA damage in rat testicular cells. FASEB J 16: 195–201.
  • Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL (1999) The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenino-quinone. Chem Res Toxicol 12: 204–213.

Typ dokumentu

Bibliografia

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