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2007 | 63 | 09 |

Tytuł artykułu

Zmiany neuropatologiczne mozgowia starych zwierzat

Autorzy

Warianty tytułu

EN
Neuropathological brain changes in elderly animals

Języki publikacji

PL

Abstrakty

EN
The aim of the study was the examine atrophy and degenerative brain changes of nine elderly animals (three monkeys, two wild cats, a likaon, a bear, a fox and horse) and to find an animal model for researching Alzheimer disease in humans. Brain hemispheres were dissected into hemispheric slabs 4.0-4.8 mm thick. Tissue samples from the brains were fixed in 10% neutral formalin, and embedded in paraffin, and then stained with hematoxylin an eosin, Nissl method, and monoclonal antibody 4G8 mAb against b-polipeptyde and neurofibrillary tangles (NFT) were stained with anti-tau monoclonal antibody. The examined animals revealed various degrees of brain atrophy neuron loss in layer III-VI in particular, lipofuscin deposit, status lacunaris, degenerative changes in the white matter, and gliosis. Lafora-like bodies were observed in licaon, horse and bear brains. The monkeys, cats, licaon, foxes, with the exception of the horse developed brain parenchymal amyloidosis-b. Two types of plaque were present, with the diffuse form being predominant. Congophilic amyloid angiopathy was observed in all the animals with the exception of the horse. NFT and amyloidosis-b was observed only in the bear brain and the latter is a good model for Alzheimer's pathology.

Wydawca

-

Rocznik

Tom

63

Numer

09

Opis fizyczny

s.1071-1076,fot.,tab.,bibliogr.

Twórcy

autor
  • Akademia Rolnicza we Wroclawiu, pl.Grunwaldzki 47, 50-366 Wroclaw
autor

Bibliografia

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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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