Dobowe zmiany szybkosci biotransformacji antypiryny u cielat

• Autorzy: Janus K , Suszycka J. , Muszczynski Z.
• Języki publikacji: PL

Abstrakty

EN

The aim of this study was to determine the „day-night” changes of the antipyrine biotransformation rate in calves. The experiment was carried out on 10 bulls-calves of the black and white breed. During the experiment the animals were kept in uniform environmental condidions and constant light/dark cycle - L/D = 12:12. The antipyrine test was performed on days 10, 20 and 40 after birth. Antipyrine was administered intravenously at a dose of 1000 mg in a 10% sterile solution. Pharmacokinetic parameters of antipyrine were calculated from the elimination curve in two time-intervals (9.00-17.00 - „day”; 21.00-5.00 - „night”), by means of the TopFit 2.0 test. Mean values of half-life and metabolic clearance of antipyrine for all examined calves (n=10) did not differ significantly. Based on results obtained in each calf, the examined population was divided into 2 groups: in 7 calves a decrease of antipyrine half-life and an increase of metabolic clearance during the day were confirmed. The observed changes increased with the age of the examined calves. A different phenomenon was observed in 3 calves - antipyrine elimination from plasma was faster during the night. Also in this case observed changes increased with the age of the calves. The initial concentration of antipyrine and the distribution coefficient did not differ significantly between day and night.

Słowa kluczowe

PL

farmakokinetyka; antypiryna; zmiennosc dobowa; cieleta; biotransformacja

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 1998
• Tom: 54
• Numer: 05
• Opis fizyczny: s.314-317,tab.,bibliogr.

Twórcy

autor

Janus K

• Akademia Rolnicza, ul. Doktora Judyma 26, 71-466 Szczecin

autor

Suszycka J.

autor

Muszczynski Z.

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