The multigene family of fatty acid-binding proteins [FABPs]: Function, structure and polymorphism

• Autorzy: Chmurzynska A
• Języki publikacji: EN

Abstrakty

EN

Fatty acid-binding proteins (FABPs) are members of the superfamily of lipid-binding proteins (LBP). So far 9 different FABPs, with tissue-specific distribution, have been identified: L (liver), I (intestinal), H (muscle and heart), A (adipocyte), E (epidermal), Il (ileal), B (brain), M (myelin) and T (testis). The primary role of all the FABP family members is regulation of fatty acid uptake and intracellular transport. The structure of all FABPs is similar- the basic motif characterizing these proteins is β-barrel, and a single ligand (e.g. a fatty acid, cholesterol, or retinoid) is bound in its internal water-filled cavity. Despite the wide variance in the protein sequence, the gene structure is identical. The FABP genes consist of 4 exons and 3 introns and a few of them are located in the same chromosomal region. For example, A-FABP, E-FABP and M-FABP create a gene cluster. Because of their physiological properties some FABP genes were tested in order to identify mutations altering lipid metabolism. Furthermore, the porcine A-FABP and H-FABP were studied as candidate genes with major effect on/fatness traits.

Słowa kluczowe

EN

multigene family; animal genetics; gene; muscle; fatness trait; liver; fatty acid-binding protein; lipid-binding protein

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2006
• Tom: 47
• Numer: 1
• Opis fizyczny: p.39-48,ref.

Twórcy

autor

Chmurzynska A

• Department of Animal Genetics and Breeding, August Cieszkowski Agricultural University of Poznan, Wolynska 33, 60-637 Poznan, Poland

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