Nucleoside phosphate analogues of biological interest, and their synthesis via aryl nucleoside H-phosphonates as intermediates

• Autorzy: Cieslak J. , Sobkowski M. , Jankowska J. , Wenska M. , Szymczak M. , Imiolczyk B. , Zagorowska I. , Shugar D. , Stawinski J. , Kraszewski A.
• Języki publikacji: EN

Abstrakty

EN

This re view pres ents a brief ac count of the chem is try and mech a nis tic as pects of aryl H-phosphonates, and se lected ap pli ca tions of this class of com pounds as in ter me di ates in the syn the sis of a wide range of bi o log i cally im por tant an a logues of nucleoside phos phates, and oligonucleotides, in which the phos phate moi eties are re placed by other struc tur ally re lated groups. The aryl nucleosideH-phosphonates, com pounds of con trolled re ac tiv ity, have proven to be more ver sa tile and su pe rior to var i ous mixed an hy drides as syn thetic in ter me di ates, par tic u larly for prep a ra tion of nu cle o tide an a- logues bearing P-N or P-S bonds in various configurational arrangements at the phos phate moi ety.

Słowa kluczowe

EN

H-phosphonamidate; nucleoside phosphate; nucleoside 2',3'-cyclic phosphate analogue; nucleophilic catalysis; aryl H-phosphonate; H-phosphono[di]thioate; oligonucleotide

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 2
• Opis fizyczny: p.429-442,fig.

Twórcy

autor

Cieslak J.

• Polish Academy of Sciences, Z.Noskowskiego 12-14, 61-704 Poznan, Poland

autor

Sobkowski M.

autor

Jankowska J.

autor

Wenska M.

autor

Szymczak M.

autor

Imiolczyk B.

autor

Zagorowska I.

autor

Shugar D.

autor

Stawinski J.

autor

Kraszewski A.

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