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2009 | 53 | 1 |

Tytuł artykułu

Assessment of the efficiency of applying methisoprinol and vaccination of turkeys against the haemorrhagic enteritis virus using in ovo methods

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the research was to determine the efficiency of in ovo immunisation of turkeys against the haemorrhagic enteritis virus, while simultaneously applying a synthetic immunomodulator - methisoprinol - by the same route of administration. Dindoral SPF vaccine, in a dose of 0.1 ml of the solution prepared ex tempore after dissolving the vaccine in 100 ml of water for injection, and methisoprinol in a dose of 5 mg per egg, were administered in ovo on the 26th d of incubation. The control groups consisted of turkeys hatched from eggs into which only the methisoprinol or the vaccine was administered, as well as birds hatched from eggs that were not interfered with. The susceptibility of turkeys to HE virus infection was determined on the basis of the presence of HE antibodies in serum, the evaluation of a splenic index, and attempts to register the virus presence in the spleen 120 h after the control infections. The research proved the effectiveness of immunising turkeys against the haemorrhagic enteritis virus by administering Dindoral SPF vaccine in ovo. It was also demonstrated that the simultaneous application of methisoprinol, showing an antiviral effect, and the vaccine inhibited the development of post vaccinal immunity against this virus.

Wydawca

-

Rocznik

Tom

53

Numer

1

Opis fizyczny

p.13-15,ref.

Twórcy

autor
  • University of Warmia and Mazury in Olsztyn, 10-957 Olsztyn, Poland
autor

Bibliografia

  • 1. Ahmad J., Sharma J.M.: Protection against hemorrhagic enteritis and Newcastle disease in turkeys by embryo vaccination with monovalent and bivalent vaccines. Avian Dis 1992, 37, 485-491.
  • 2. Andrzejewski M.: The influence of methisoprinol applied in ovo upon the immunity system and selected biochemical blood parameters in turkeys. Doctoral thesis, Olsztyn, 2007.
  • 3. Dietert R.R., Lamont S.J.: Avian immunology: from fundamental immune mechanism to the integrative management of poultry. Poult Sci 1994, 73, 975-978.
  • 4. Dohms J.E., Saif Y.M.: Criteria for evaluation immunosuppression. Avian Dis 1997, 28, 305-310.
  • 5. Fadly A.M., Nazerian K.: Hemorrhagic enteritis of turkeys: influence of maternal antibody and age at exposure. Avian Dis 1989, 33, 778-786.
  • 6. Gordon P.: The antiviral activity of isoprinosine. Can J Microbiol 1972, 18, 1463-1470.
  • 7. Gordon P., Ronsen B., Brown E.R.: Anti-herpesvirus action of isoprinosine. Antimicrob Agents Chemoth 1974, 18, 153-160.
  • 8. Guiro S.: Investigations on the immunosuppressive effect of hemorrhagic enteritis virus (HEV) infection in turkeys. Doctoral thesis, Olsztyn, 2000.
  • 9. Guiro S., Koncicki A.: Vaccination against NDV in turkeys infected by haemorrhagic enteritis virus. Medycyna Wet 2004, 60, 871-873.
  • 10. Johnston P.A., Liu H., O'Connell, Phelps P., Bland M., Tyczkowski J., Kemper A., Harding T., Avakian A., Haddad E., Whitfill C., Gildersleeve R., Ricks C.A.: Applications of in ovo technology. Poultry Sci 1997, 76, 165-178.
  • 11. Koncicki A.: Characteristics of domestic adenovirus isolates of hemorrhagic enteritis (HE) in turkeys and evaluation of epizootic situation in Poland. Acta Acad Agricult Tech Olst Veterinaria 1996, 22, 1-43.
  • 12. Koncicki A., Rumińska E., Stenzel T., Mazur- Gonkowska B., Tykałowski B.: Application of isoprinosine in ovo to immunomodulation in turkeys. XIX International Poultry Symposium, PB WPSA Olsztyn, 2007, p. 63.
  • 13. Małaczewska J., Rotkiewicz Z.: Effect of methisoprinol on virus replication in cell cultures. Polish J Vet Sci 2004, 7, 97-102.
  • 14. Małaczewska J., Rotkiewicz Z.: Biological properties of Roakin strain of NDV and TK900 strain of ADV after serial passages in CECC in the presence of methisoprinol and KLP-602. Polish J Vet Sci 2005, 8, 23-28.
  • 15. Małaczewska J., Rotkiewicz Z.: Effect of methisoprinol and KLP-602 on virus replication in chicken embryos. Polish J Vet Sci 2005, 8, 289-294.
  • 16. Nagaraja K.V., Patel B.L., Emery D.A., Pomeroy B.S., Newman J.A.: In vitro depression of the mitogenic response of lymphocytes from turkeys infected with hemorrhagic enteritis virus. Am J Vet Res 1982, 43, 134-136.
  • 17. Nagaraja K.V., Patel B.L., Emery D.A., Pomeroy B.S., Newman J.A.: In vitro evaluation of B-lymphocyte function in turkeys infected with hemorrhagic enteritis virus. Am J Vet Res 1982, 43, 502-504.
  • 18. Neumann U., Sander I., Rautenschlein S., Bahr H.P., Baron G.: Krwotoczne zapalenie jelit u indyków. Aspekty patogenezy i uodporniania. Proceedings of VII Poultry Symposium, Polanica Zdrój 1997, pp. 70-77.
  • 19. Rumińska-Groda E.: The influence of isoprinosine on the immunological dynamic phenomenon as well as on the course of HEV and E. coli infection in turkeys. Doctoral thesis, Olsztyn, 2002.
  • 20. Seto F.: Early development of avian immune system. Poult Sci 1981, 60, 1981-1995.
  • 21. Sharma J.M., Karaca K., Pertile T.: Virus-induced immunosuppression in chickens. Poult Sci 1994, 73, 1082-1086.
  • 22. Sharma J.M.: The structure and function of the avian immune system. Acta Vet Hung 1997, 45, 229-238.
  • 23. Stenzel T., Tykałowski B., Andrzejewski M., Koncicki A.: The influence of methisoprinol applied in ovo on the percentage of CD3+, CD4+, and CD8+ T-lymphocyte subpopulations in turkeys. Medycyna Wet 2008, 64, 1157-1160.
  • 24. Van den Hurk J.V., Allan B.J., Riddell C., Watts T., Potter A.A.: Effect of infection with hemmorrhagic enteritis virus on susceptibility of turkeys to Escherichia coli. Avian Dis 1994, 38, 708-716.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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